Alcet Tablet, Syrup
Alcet is a potent and highly selective antagonist of the peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels and respiratory tract.
Alcet is used for the treatment of seasonal allergic rhinitis and conjunctivitis, perennial allergic rhinitis, pruritus and urticaria. It is also used in allergen induced asthma.
Alcet is also used to associated treatment for these conditions: Chronic Idiopathic Urticaria, Flu caused by Influenza, Perennial Allergic Rhinitis (PAR), Pollen Allergy, Respiratory Allergy, Seasonal Allergic Rhinitis
|Cetirizine Other Names||Cetirizin, Cetirizina, Cetirizine, Cetirizinum|
|Weight||5mg, 2.5mg/5ml, 5mg/5ml|
The mean plasma protein binding of cetirizine is 93% .
|Therapeutic Class||Sedating Anti-histamine|
|Manufacturer||Osper Pharmaceuticls Pvt Ltd, Prism Lifescience, Healthcare Pharmacuticals Ltd, Imedco Farma|
|Available Country||India, Bangladesh, Indonesia|
|Last Updated:||June 23, 2021 at 9:08 am|
- Adults and children over 6 years: 1 tablet (10 mg) once daily or ½ tablet twice daily.
- Children 2-6 years: ½ tablet once daily.
- Adults and children over 6 years: 2 teaspoonful (10 mg) once daily or 1 teaspoon (5 mg) twice daily.
- Children 2-6 years: 1 teaspoonful once daily or ½ teaspoon twice daily.
Alcet dihydrochloride is well tolerated. Lower incidence of sedation, headache, dry mouth, and gastrointestinal disturbances may occur. It does not produce anticholinergic effects.
Caution should be exercised when driving a car or operating a heavy machinery. Concurrent use of cetirizine with alcohol or other CNS depressants should be avoided because additional reduction in alertness and CNS performance may occur.
No clinically significant drug interactions have been found with theophylline, azithromycin, pseudoephedrine, ketoconazole or erythromycin and with some other drugs.
- Avoid alcohol.
- Take with or without food. The absorption is unaffected by food.
Volume of Distribution
Apparent volume of distribution: 0.44 +/- 0.19 L/kg .
Plasma elimination half-life is 8.3 hours .
Apparent total body clearance: approximately 53 mL/min .
Alcet is mainly eliminated by the kidneys , . Dose adjustment is required for patients with moderate to severe renal impairment and in patients on hemodialysis .
Pregnancy & Breastfeeding use
Pregnancy category B. There are no adequate and well controlled studies in pregnant women. Alcet should be used during pregnancy only if clearly needed. Alcet has been reported to be excreted in human breast milk. As large amount of drugs are excreted in human milk, use of Alcet in nursing mother is not recommended.
Alcet Dihydrochloride is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients or hydroxyzine.
Symptoms: Confusion, dizziness, fatigue, headache, malaise, restlessness, sedation, somnolence, diarrhoea, mydriasis, pruritus, stupor, tachycardia, tremor, and urinary retention.
Management: Symptomatic and supportive treatment. Gastric lavage may be done shortly following ingestion.
Store between 20-25°C. Syrup: Store between 2-8°C.