Agalsidase Alfa

Agalsidase Alfa Uses, Dosage, Side Effects, Food Interaction and all others data.

Agalsidase Alfa is a recombinant human α-galactosidase A similar to agalsidase beta. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta. Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa, after a contamination event in 2009.

Agalsidase Alfa was granted EMA approval on 3 August 2001.

Agalsidase Alfa is a recombinant human α-galactosidase A used as enzyme replacement therapy in the treatment of Fabry disease. It has a long duration of action and a wide therapeutic index. Patients should be counselled regarding the risk of infusion related reactions and hypersensitivity.

Trade Name Agalsidase Alfa
Generic Agalsidase alfa
Agalsidase alfa Other Names Agalsidase alfa, Agalsidase alfa (genetical recombination), Agalsidase alpha, alpha-D-galactopyranosidase, alpha-D-galactosidase, alpha-D-galactosidase enzyme, alpha-D-galactoside galactohydrolase, alpha-galactisidase, alpha-galactosidase A, Recombinant alpha-galactosidase A
Type
Formula C2029H3080N544O587S27
Weight 45351.6 Da
Protein binding

Agalsidase alfa is not expected to be protein bound in circulation.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Agalsidase Alfa
Agalsidase Alfa

Uses

Agalsidase Alfa is a recombinant human alpha-galactosidase indicated to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.

Agalsidase Alfa is indicated in the treatment of Fabry disease.

Agalsidase Alfa is also used to associated treatment for these conditions: Fabry's Disease, Enzyme replacement

How Agalsidase Alfa works

α-galactosidase A is uptaken by cells via the mannose 6 phosphate receptor. Agalsidase Alfa hydrolyzes globotriaosylceramide and other glycosphingolipids that would normally be hydrolyzed by endogenous α-galactosidase A. Preventing the accumulation of glycosphingolipids prevents or reduces the severity of manifestations of Fabry disease such as renal failure, cardiomyopathy, or cerebrovascular events.

Toxicity

Data regarding overdoses of agalsidase alfa are not readily available. Patients experiencing an overdose of agalsidase alfa may experience an increased incidence and severity of adverse effects. Overdose can be managed through the use of symptomatic and supportive measures.

Food Interaction

No interactions found.

Volume of Distribution

The volume of distribution at steady state in non end stage renal disease patients was approximately 17% of body weight regardless of sex.

Elimination Route

A dose of agalsidase alfa in non end stage renal disease patients reaches a Cmax of 3710 ± 855 U/mL with an AUC of 256,958 ± 63,499 min*U/mL.

Half Life

The elimination half life was 108 ± 17 minutes for males and 89 ± 28 minutes for females.

Clearance

The clearance for doses of 0.007-0.2 mg/kg were 2.66 mL/min/kg for males and 2.10 mL/min/kg for females.

Elimination Route

After nonspecific proteolysis, the amino acids from protein drugs are reused for protein synthesis or further broken down and eliminated by the kidneys.

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