Adifex Hydrochloride is an antihistamine with selective peripheral H1 receptor antagonist activity. It inhibits histamine release from peritoneal mast cells. No anticholinergic, α-1 adrenergic or β-adrenergic receptor blocking effects has been observed. No sedative or other central nervous system effect has been observed. It does not appear to cross the blood brain barrier.
Adifex is rapidly absorbed after oral administration with peak plasma concentration being reached in 2-3 hours. Elimination half-life of about 14 hours has been reported although this may be prolonged in patients with renal impairment.
It is used for the relief of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.
Adifex is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Chronic Idiopathic Urticaria, Seasonal Allergic Rhinitis, Antihistamine
|Fexofenadine Other Names||Carboxyterfenadine, Fexofenadina, Fexofenadine, Terfenadine acid metabolite, Terfenadine carboxylate, Terfenadine-COOH|
Fexofenadine is 60-70% bound to plasma proteins, primarily to albumin and α1-acid glycoprotein. The extent of protein binding is decreased to 56-68% and 56-75% in patients with renal and hepatic impairment, respectively.
|Therapeutic Class||Non-sedating antihistamines|
|Manufacturer||United Chemicals &, Pharmaceuticals Ltd|
|Last Updated:||June 23, 2021 at 11:20 am|
- Allergic rhinitis: 120 mg once daily or 60 mg twice daily
- Urticaria: 180 mg once daily
- 2-11 years: 30 mg (1 spoonful) or 5 ml twice daily
- 6 months-2 years: 15 mg (1/2 spoonful) or 2.5 ml twice daily
In case of decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function.
Adifex is generally well tolerated. The most commonly reported adverse events are headache, drowsiness, nausea, and dizziness. The incidence of these events observed with Adifex hydrochloride was similar to that observed with placebo.
Studies in the elderly, patients with hepatic impairment and patients with cardiac disease exposed to Adifex showed no statistically significant differences compared to healthy individuals. As with most new drugs there is only limited data in the elderly and renally or hepatically impaired patients. Adifex hydrochloride should be administered with care in these special groups.
Co-administration of Adifex Hydrochloride with either ketoconazole or erythromycin may cause increased plasma concentration of Adifex. Antacid containing Aluminium and Magnesium may reduce the absorption of Adifex. Fruit juices such as grapefruit, orange and apple may reduce the bioavailability of Adifex.
- Avoid fruit juice. Fruit juices like grapefruit, orange, and apple may reduce bioavailability and overall exposure to the medication.
- Take with or without food. Co-administration with food does not significantly affect absorption.
Volume of Distribution
The volume of distribution is approximately 5.4-5.8 L/kg.
The terminal elimination half-life is approximately 11-15 hours.
The oral clearance of fexofenadine is approximately 50.6 L/h and the renal clearance is approximately 4.32 L/h.
Pregnancy & Breastfeeding use
Pregnancy Category B. There are no adequate and well controlled studies in pregnant women. Adifex should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation: It is not known if Adifex is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Adifex is administered to a nursing woman.
Adifex is contraindicated in patients with known hypersensitivity to Adifex or any of the ingredients of Adifex Hydrochloride.
Studies in special risk groups (elderly, renally or hepatically impaired patients) indicate that it is not necessary to adjust the dose of Adifex Hydrochloride in these patients.
In case of an overdose, standard measures to remove any unabsorbed drug should be employed. Symptomatic and supportive treatment is recommended. There has been no reported case of an acute overdose of Adifex hydrochloride.
Store Adifex at controlled room temperature 20-25 °C. Keep all medicines away from reach of children.
What is Adifex used to treat?
Adifex is an antihistamine medicine that helps with the symptoms of allergies. It's used to treat: hay fever. conjunctivitis (red, itchy eye)
When is it best to take Adifex?
You should take Adifex before a meal where possible. Some people find it helps to swallow the tablet with a drink of water. Try to take the tablets at the same time of day each day, as this will help you to remember to take them
Should Adifex be taken in the morning or at night?
If you are taking a 12 hour form of Adifex, it can be taken once in the morning and once in the evening. If you are taking an Adifex once-a-day 24 hour tablet, it can be taken at any time of the day.
Who should not take Adifex?
Ask a doctor before using this medicine if you are pregnant or breastfeeding. Older adults may be more sensitive to the effects of this medicine. If you are 65 or older, ask a doctor before taking Adifex. This medicine may contain phenylalanine.
Does Adifex raise blood pressure?
However, medicines containing decongestants including Adifex could increase your blood pressure and heart rate or interfere with your heart medication.
Can Adifex cause high cholesterol?
The low dose of cetirizine did not affect serum lipid levels. On the other hand, the low dose of Adifex significantly increased LDL cholesterol.
Can Adifex cause heart palpitations?
Adifex is often given chronically, at least during allergic season. Common side effects include blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache.
Can I take Adifex at night?
As well as taking a non-drowsy antihistamine during the day (such as Adifex, cetirizine or loratadine), your doctor may suggest that you take a sedating antihistamine at night time if the itching is making it difficult to sleep
How long does Adifex last?
This medicine starts to relieve your symptoms within 1 hour and lasts for 24 hours
Is Adifex safe to take pregnancy time?
Adifex use during pregnancy does not appear to be associated with a risk of adverse fetal outcomes; the results indicate that Adifex may have a fetal safety profile comparable to that of the currently recommended second-generation antihistamines during pregnancy.
Is Adifex safe for long term use?
Doses up to 240mg once daily for up to 12 months in healthy volunteers, is safe and well tolerated.
Can Adifex cause a sore throat?
Common side effects may include: headache, back pain,or cold symptoms such as stuffy nose, sinus pain, sore throat.
Does Adifex cause anxiety?
Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: fast/irregular/pounding heartbeat, shaking (tremor), mental/mood changes (such as anxiety, confusion, nervousness, restlessness), problems urinating.
Can Adifex cause chest pain?
Allergic reactions to the medicine, which may cause swelling of the face, lips, tongue or throat, difficulty breathing, chest tightness or flushing.
Is Adifex a stimulant?
Although antihistamines are known for their sedative adverse effects, Adifex was previously shown to have stimulating effects. These stimulant effects were rather mild in magnitude and were only demonstrated in tasks with a high workload.
How good is Adifex hydrochloride?
Adifex has an average rating of 6.3 out of 10 from a total of 149 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 31% reported a negative effect.
Is it safe to take Adifex everyday?
May be given daily on a regular basis when allergens are most prevalent (such as during spring or summer). Adifex is approved for use in children older than 6 months with chronic urticaria and those older than two years with seasonal allergic rhinitis.
Is there anything stronger than Adifex?
Several studies have found cetirizine to be more effective than Adifex at relieving symptoms of allergic rhinitis and urticaria, and it appears to have a longer duration of action.
How long does Adifex take to work?
Adifex usually starts to work within half an hour to an hour after taking a dose.
How effective is Adifex?
Adifex was effective in relieving the symptoms of sneezing, rhinorrhoea, itchy nose palate or throat, and itchy, watery, red eyes in patients with seasonal allergic rhinitis. There were often small improvements in nasal congestion that were further improved by pseudoephedrine.
Can Adifex be cut in half?
Do not split, crush, or chew it.Adifex tablets can safely be cut or split in half.
Can I drink orange juice with Adifex?
Do not drink grapefruit juice, apple juice or orange juice while you're taking Adifex. It might make you more likely to get side effects. It's best not to drink alcohol while you're taking Adifex as it can make you feel sleepy.