Actinion Cream

Actinion is structurally and pharmacologically related to vitamin A. Current evidence suggests that topical Actinion decreases cohesiveness of follicular epithelial cells with decreased microcomedone formation. Additionally, Actinion stimulates mitotic activity and increases turnover of follicular epithelial cells, causing extrusion of the comedones


  • For the treatment of acne vulgaris in which comedones, papules and pustules predominate.
  • For the treatment of hyperpigmentation, roughness and fine wrinkling of photodamaged skin due to chronic sun exposure.
  • For the treatment of Acute promyelocytic leukaemia

Actinion is also used to associated treatment for these conditions: Acne Vulgaris, Alopecia, Cornification and dystrophic skin disorders, FAB classification M3 Acute promyelocytic leukemia, Skin hyperpigmentation, Solar Lentigines, Facial fine wrinkling, Keratinization disorders of the feet, Keratinization disorders of the hand, Moderate Melasma, Mottled hyperpigmentation, Severe Melasma, Severe, recalcitrant Cystic acne, Tactile roughness of facial skin

Trade Name Actinion
Generic Tretinoin
Other Names Acide retinoique, all trans Retinoic acid, all trans-Retinoic acid, all-(E)-Retinoic acid, all-trans-Retinoic acid, all-trans-Tretinoin, all-trans-Vitamin A acid, all-trans-Vitamin A1 acid, ATRA, beta-Retinoic acid, Retinoic acid, Retionic acid, trans-Retinoic acid, Tretin M, Tretinoin, Tretinoina, Trétinoïne, Tretinoinum, Vitamin A acid
Weight 05%
Type Cream
Formula C20H28O2
Weight Average: 300.442
Monoisotopic: 300.208930142
Protein binding

> 95%

Therapeutic Class Topical retinoid and related preparations
Manufacturer Drug International Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:26 am


Actinion dosage

Actinion cream: Actinion cream should be applied sparingly to the whole affected area once or twice daily. The skin should be thoroughly cleaned and dried before application. Patient should be advised that 6 to 8 weeks of treatment may be required before a therapeutic effect is observed. Moisturisers and cosmetics may be used during treatment with Cosmotrin cream but should not be applied to the skin at the same time. Astringent toiletries should be avoided.    

Actinion gel: Actinion gel should be applied once or twice a day, before retiring, to the skin where lesions appear, using enough to cover the entire affected area lightly. The frequency of application can be adjusted to obtain maximum clinical efficacy with minimal erythema and scaling.    

If Actinion gel is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur. Should this occur accidentally or through over-enthusiastic use, application should be discontinued for few days.    

Patience is needed in this treatment, since the therapeutic effects will not usually be observed until after 6-8 weeks of treatment. During the early weeks of treatment, an apparent exacerbation of inflammatory lesions may occur. This is due to the action of the medication on deep, previously unseen comedones and papules. Once the acne lesions have responded satisfactorily, it should be possible to maintain the improvement with less frequent applications.    

Moisturizers and cosmetics may be used during treatment with Actinion gel but should not be applied to the skin at the same time. The skin should be thoroughly washed before application of Actinion gel. Astringent toiletries should be avoided.    

Capsule: The recommended dose is 45 mg/m2/day administered as two evenly divided doses until complete remission is documented. Therapy should be discontinued 30 days after achievement of complete remission or after 90 days of treatment, whichever occurs first.    

If after initiation of treatment of Actinion the presence of the translocation is not confirmed by cytogenetics and/or by polymerase chain reaction studies and the patient has not responded to Actinion, alternative therapy appropriate for acute myelogenous leukemia should be considered.

Side Effects

True allergic contact dermatitis is rare but a primary irritant dermatitis, manifesting itself as irritation, erythema, peeling and sensation of warmth, is common. Slight stinging is common as a mild reaction in many people but usually settles with continuous use and/or reduction in the frequency of application of the drug.


Particular caution should be exercised in using preparations containing peeling agents (i.e. sulfur, resorcinol, benzoyl peroxide or salicylic acid). Use of topical preparations with high concentrations of alcohol, menthol, spices or lime- such as shaving lotions, astringents and perfume- should be avoided, especially during initial therapy.

Food Interaction

  • Take with food. Actinion absorption may be increased by co-administration with food.

Half Life

0.5-2 hours

Pregnancy & Breastfeeding use

Actinion is contraindicated in pregnancy or suspected pregnancy. The drug should be avoided by breast feeding mothers.


Actinion is contraindicated in patients who are allergic to this drug. It is contraindicated in pregnancy or suspected pregnancy. It is also contraindicated in personal or familial history of cutaneous epithelioma.    

Local irritation: The presence of cutaneous irritative signs (e.g. erythema, peeling, pruritus, sunburn, etc.) should prohibit initiation or recommencement of treatment with Actinion until the symptoms resolve. Actinion has been reported to cause severe irritation on eczematous skin  and should be used with caution in patients with this condition.    

Exposure to sunlight: Exposure to sunlight, including ultraviolet sun-lamps, should be avoided or minimised during the use of Actinion.    

General precaution: Before application of Actinion, areas to be treated should be cleansed thoroughly. Abstain from washing the treated area frequently; twice daily is sufficient. Use of mild soap is recommended. Dry the skin without rubbing.    

Avoid contact with eyes, eyelids, nostrils, mouth and mucous membranes. If contact in these areas occurs, careful washing with water is recommended.

Storage Condition

Store in a cool and dry place, away from light. Keep out of reach of children.

Actinion contains Tretinoin see full prescribing information from innovator Monograph