Acliz has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Acliz has an onset of action of 30 to 60 minutes, depending on dosage; their duration of action is 12 to 24 hours.
Acliz Hydrochloride is used for nausea, vomiting, motion sickness, vertigo.
Acliz is also used to associated treatment for these conditions: Dizziness, Motion Sickness
|Other Names||Meclizine, Meclozina, Meclozine|
There is limited data on the protein binding profile of meclizine.
|Therapeutic Class||Anti-emetic drugs|
|Last Updated:||June 23, 2021 at 11:22 am|
Table Of contents
Adult & children over 12 years of age:
- Nausea and vomiting: 25-50 mg once daily.
- Motion sickness: Take an initial dose of 25 to 50 mg, 1 hour prior to travel. May repeat dose every 24 hours for the duration of the journey. Children: Age 6-12 years, 12.5 mg once daily. Age 2-6 years, 6.25 mg once daily.
- Vertigo: 25 to 100 mg daily in divided doses.
- Radiotherapy induced nausea and vomiting: 50 mg two to twelve hours prior to radiotherapy.
- Emergency contraception: 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.
Use in children: Clinical studies establishing safety and efficacy in children have not been done; therefore, its use should be determined by physician.
Use in elderly: There is no specific information available. However older people may be especially sensitive to the anticholinergic effects of medicine.
Common side effects are Drowsiness, dry mouth, and on rare occasions, blurred vision have been reported.
Patients with asthma, bronchitis, emphysema, enlarged prostate, glaucoma or urinary tract blockage should take Acliz (like other antiemetics) with caution.
Acliz may increase the toxicity with CNS depressants, neuroleptics and anticholinergic. Alcohol, sedatives and tranquilizers can increase the drowsiness of the patient.
- Avoid alcohol. Alcohol may cause additive CNS depressant effects.
Volume of Distribution
The volume of distribution of meclizine in humans has not been fully studied. It is proposed that meclizine may be excreted into breast milk.
Acliz has a plasma elimination half-life of about 5-6 hours in humans.
There is limited data on the clearance of meclizine.
Pregnancy & Breastfeeding use
Acliz shows no risk of birth defects or abnormalities when administered during pregnancy. Although Acliz may excrete into the milk, it causes no harm in nursing babies.
Acliz is contraindicated in patients hypersensitive to Acliz or any of its excipeints.
Symptoms: Extreme excitability, seizures, drowsiness and hallucinations.
Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis.
Store in a cool & dry place and away from children.