Acide Carglumique

Acide Carglumique Uses, Dosage, Side Effects, Food Interaction and all others data.

Acide Carglumique is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Acide Carglumique was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010.

The median Tmax of Carbaglu was 3 hours (range: 2-4). The daily dose of carglumic acid ranges from 100 to 250 mg/kg and this does are normally adjusted to maintain normal plasma levels of ammonia.

Trade Name Acide Carglumique
Generic Carglumic acid
Carglumic acid Other Names Acide carglumique, ácido carglúmico, Acidum carglumicum, Carbamino-L-glutamic acid, Carbamylglutamic acid, Carglumic acid, N-Carbamylglutamate, Ureidoglutaric acid
Type
Formula C6H10N2O5
Weight Average: 190.154
Monoisotopic: 190.05897144
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Acide Carglumique
Acide Carglumique

Uses

Acide Carglumique is an analog of N-acetylglutamate (NAG) used for the treatment of acute and chronic hyperammonemia in patients with N-acetylglutamate synthase (NAGS) deficiency.

For the treatment of acute and chronic hyperammonaemia in patients with N-acetylglutamate synthase (NAGS) deficiency. This enzyme is an important component of the urea cycle to prevent build up of neurotoxic ammonium in the blood.

Acide Carglumique is also used to associated treatment for these conditions: Hyperammonaemia

How Acide Carglumique works

Acide Carglumique is a synthetic structural analogue of N-acetylglutamate (NAG), which is an essential allosteric activator of the liver enzyme carbamoyl phosphate synthetase 1 (CPS1). CPS1 is found in the mitochondria and is the first enzyme of the urea cycle, which converts ammonia into urea. Acide Carglumique acts as a replacement for NAG in NAGS deficiency patients by activating CPS1 but it does not help to regulate the urea cycle.

Toxicity

LD50, oral, mouse: >1000 mg/kg

Food Interaction

  • Take before a meal. Take carglumic acid right before eating.
  • Take with plain water. Acide Carglumique tablets are dispersed in water to produce an oral suspension and should not be swallowed whole.

Volume of Distribution

The apparent volume of distribution was 2657 L (range: 1616-5797).

Elimination Route

30% bioavailability; Cmax, mean, 100 mg/kg dose = 2.6 μg/mL (range of 1.9 - 4.8)
Acide Carglumique is not subject to to intracellular degradation.

Half Life

Median values for the terminal half-life was 5.6 hours (range 4.3-9.5).

Clearance

The apparent total clearance was 5.7 L/min (range 3.0-9.7), the renal clearance was 290 mL/min (range 204-445), and the 24-hour urinary excretion was 4.5 % of the dose (range 3.5-7.5).

Elimination Route

Following administration of a single radiolabeled oral dose of 100 mg/kg of body weight, 9% of the dose was excreted unchanged in the urine and up to 60% of the dose was excreted unchanged in the feces.

Innovators Monograph

You find simplified version here Acide Carglumique

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0000265
http://classyfire.wishartlab.com/tax_nodes/C0000013
http://classyfire.wishartlab.com/tax_nodes/C0004323
http://classyfire.wishartlab.com/tax_nodes/C0000262
http://classyfire.wishartlab.com/tax_nodes/C0000346
http://classyfire.wishartlab.com/tax_nodes/C0001231
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0003152
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0000117
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:71028
http://www.hmdb.ca/metabolites/HMDB0015673
http://www.genome.jp/dbget-bin/www_bget?drug:D07130
http://www.genome.jp/dbget-bin/www_bget?cpd:C05829
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=121396
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443290
https://www.chemspider.com/Chemical-Structure.108351.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=401713
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=71028
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201780
https://zinc.docking.org/substances/ZINC000001530283
http://www.pharmgkb.org/drug/PA165958402
http://www.rxlist.com/carbaglu-drug.htm
https://www.drugs.com/carbaglu.html
https://en.wikipedia.org/wiki/Carglumic_acid
*** Taking medicines without doctor's advice can cause long-term problems.
Share