Acicot Syrup, Eye/ear Drops
Acicot protects GI lining against peptic acid, pepsin and bile salts by binding with positively-charged proteins in exudates forming a viscous paste-like adhesive substance thus forming a protective coating.
Acicot tablet is used for the treatment of acute, nonmalignant gastric and duodenal ulcers. Maintenance therapy to prevent the recurrence of duodenal ulcers.
Acicot suspension is used for the short-term (up to 8 weeks) treatment of active duodenal ulcer.
Acicot is also used to associated treatment for these conditions: Dyspepsia, Gastric Ulcer, Gastritis, Gastro-esophageal Reflux Disease (GERD), Healing, Mucositis, Peptic Ulcer, Stress Ulcers, Active Duodenal ulcer, Antiplatelet Therapy
|Other Names||Sucralfat, Sucralfate, Sucralfato, Sucralfatum|
|Type||Syrup, Eye/ear Drops|
Sucralfate is bound to plasma proteins, especially albumin and transferrin .
|Therapeutic Class||Chelating complex|
|Manufacturer||Skymax Laboratories Ltd, Aci Limited|
|Available Country||India, Bangladesh|
|Last Updated:||June 23, 2021 at 9:00 am|
Table Of contents
Adult: Usual dose 1 gm 4 times daily to be taken 1 hour before meals and at bed time. Maximum daily dose is 8 gm. Four to six weeks treatment is usually needed for ulcer healing but upto twelve weeks may be necessary in resistant cases. Antacids may be used as required for relief of pain, but should not be taken half an hour before or after Gastalfet.
Elderly: There are no special dosage requirements for elderly patients but as with all medicines the lowest effective dose should be used.
children: Safety and efficacy in children have not been established
The incidence and severity of side effects from sucralfate are very low. Mild side effect like constipation has been reported in some patients.
The product should only be used with caution in patients with renal dysfunction
Concomitant use of sucralfate may reduce the bioavailability of certain drugs as has been observed in animal studies with tetracycline, phenytoin and cimetidine and in human studies with digoxin. Administration of sucralfate with any of these drugs should be separated by two hours. Since sucralfate may hinder warfarin absorption, caution should be exercised when these two drugs are used together.
- Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
- Take separate from antacids. Take at least 30 minutes before or after antacids.
Volume of Distribution
This drug is absorbed in a very small quantity, and normally localizes to inflamed gastrointestinal lesions .
The half-life is not known. In animals, the elimination half-life of the sucrose component of this drug is from 6-20 h .
Acicot contains aluminum. The administration of sucralfate in non-dialyzed chronic renal failure patients warrants careful consideration from the treating physician as the excretion of absorbed aluminum may be decreased, causing possible aluminum toxicity .
In dialyzed patients diagnosed with chronic renal failure, aluminum toxicity related to sucralfate has been observed and reported. The daily amount of aluminum ingestion (including sucralfate) should be carefully examined before administering sucralfate in combination with other drugs also containing aluminum, including various antacids .
Pregnancy & Breastfeeding use
Although animal studies show no evidence of foetal malformation, safety in pregnant women has not been established and Acicot should be used in pregnancy only if clearly needed.
It is not known whether this drug is excreted in human milk. Caution should be exercised when sucralfate is administered to nursing mothers.
There are no known contraindications
There is no experience in human with overdosage
Store at 20-25° C.
What is Acicot used for?
Acicot is used short-term (up to 8 weeks) to treat an active duodenal ulcer. Acicot works mainly in the lining of the stomach and is not highly absorbed into the body. This medicine adheres to ulcer sites and protects them from acids, enzymes, and bile salts.
Is Acicot good for acid reflux?
Acicot and omeprazole are used to treat ulcers and gastroesophageal reflux disease (GERD). Omeprazole is also used to treat Zollinger-Ellison syndrome, duodenitis, erosive esophagitis, heartburn, and H. pylori infection.
What are side effects of Acicot?
Acicot side effects are Constipation, dry mouth, upset stomach, gas, and nausea may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
What are the side effects of Acicot?
Acicot Side effects are include:
- Back pain
- Dry mouth
- Gas (flatulence)
- Itching or skin rash
- Sleep problems (insomnia)
- Spinning sensation (vertigo)
- Stomach pain
- Upset stomach
Is Acicot bad for kidneys?
Aluminum accumulation and toxicity have been reported with the use of sucralfate in patients with compromised renal function. The risk of toxicity most likely represents a long-term complication of Acicot use in this patient population.
Does Acicot cure gastritis?
Acicot is the primary agent for prophylaxis of stress gastritis. It has long been used as a means of decreasing the incidence of gastritis.
Can I drink water while taking Acicot?
Take Acicot by mouth with a glass of water. Follow the directions on the prescription label. This medicine works best if you take it on an empty stomach, 1 hour before meals. Take your doses at regular intervals.
Does Acicot help with gas?
Acicot administration was accompanied by the disappearance of heartburn, epigastric pain, epigastric distress, or epigastric burning in 42 of 59 occurrences, and by statistically significant reductions in bloating.
What is the best time to take Acicot?
Take Acicot on an empty stomach, 2 hours after or 1 hour before meals. Take Acicot around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
What should not take with Acicot?
Some antacids can make it harder for Acicot to work in your stomach. Avoid taking an antacid within 30 minutes before or after taking Acicot.
Can Acicot cause loose stools?
Acicot may cause constipation, diarrhea, nausea, and headache.
Can Acicot cause frequent urination?
This medicine may affect your blood sugar levels. Check with your doctor right away if you have increased thirst or increased urination.
What color is urine when your kidneys are failing?
When kidneys are failing, the increased concentration and accumulation of substances in urine lead to a darker color which may be brown, red or purple. The color change is due to abnormal protein or sugar, high levels of red and white blood cells, and high numbers of tube-shaped particles called cellular casts.
Does Acicot really work?
Acicot has an average rating of 5.7 out of 10 from a total of 50 ratings for the treatment of Stomach Ulcer. 38% of those users who reviewed Acicot reported a positive effect, while 30% reported a negative effect.
Does Acicot coat the stomach?
Acicot is used to treat and prevent duodenal ulcers and other conditions as determined by your doctor. It works by forming a barrier or coat over the ulcer. This protects the ulcer from the acid of the stomach, allowing it to heal.
Why Acicot should not be used with antacids?
As the Acicot is effective only in acid conditions, an antacid should not be taken 30 min before or after a dose. Acicot interferes with absorption of several drugs, including ciprofloxacin, theophylline, digoxin, phenytoin and amitriptyline, possibly by binding due to its strong negative charge.