3-n-propylxanthine

3-n-propylxanthine Uses, Dosage, Side Effects, Food Interaction and all others data.

3-n-propylxanthine is a derivative of theophylline which shares bronchodilator properties. 3-n-propylxanthine is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Long-term enprofylline administration may be associated with elevation in liver enzyme levels and unpredictable blood levels.

3-n-propylxanthine is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.

3-n-propylxanthine
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Trade Name	3-n-propylxanthine
Generic	Enprofylline
Enprofylline Other Names	3-n-propylxanthine, 3-propylxanthine, Enprofilina, Enprofylline, Enprofyllinum
Type
Formula	C₈H₁₀N₄O₂
Weight	Average: 194.1906 Monoisotopic: 194.080375584
Protein binding	49%
Groups	Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.

How 3-n-propylxanthine works

3-n-propylxanthine inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.