3'-C-Ethynylcytidine Uses, Dosage, Side Effects, Food Interaction and all others data.

3'-C-Ethynylcytidine is a new nucleoside antimetabolite. 3'-C-Ethynylcytidine has demonstrated strong antitumor activity without serious toxicity in nude rat models bearing human tumours .

Trade Name 3'-C-Ethynylcytidine
Generic TAS-106
TAS-106 Other Names 3'-C-Ethynylcytidine
Formula C11H13N3O5
Weight Average: 267.241
Monoisotopic: 267.085520531
Groups Investigational
Therapeutic Class
Available Country
Last Updated: September 19, 2023 at 7:00 am


Investigated for use/treatment in solid tumors and cancer/tumors (unspecified).

How 3'-C-Ethynylcytidine works

3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule.

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