2-Methoxytrimeprazine

2-Methoxytrimeprazine Uses, Dosage, Side Effects, Food Interaction and all others data.

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

2-Methoxytrimeprazine is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

Trade Name 2-Methoxytrimeprazine
Availability Discontinued
Generic Methotrimeprazine
Methotrimeprazine Other Names 2-Methoxytrimeprazine, Levomepromazina, Levomepromazine, Lévomépromazine, Levomepromazinum, Methotrimeprazine
Type
Formula C19H24N2OS
Weight Average: 328.472
Monoisotopic: 328.16093409
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
2-Methoxytrimeprazine
2-Methoxytrimeprazine

Uses

2-Methoxytrimeprazine is a phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.

For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.

2-Methoxytrimeprazine is also used to associated treatment for these conditions: Amnesia, Anxiety, Bipolar Affective Disorders, Nausea and vomiting, Pain, Cancer, Phantom Limb Pain (PLP), Post-Herpetic Neuralgia (PHN), Schizophrenia, Senile psychosis, Trigeminal Neuralgia (TN), Neurocostal neuralgia, Perioperative analgesia

How 2-Methoxytrimeprazine works

2-Methoxytrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role.

Toxicity

Symptoms of overdose include convulsions, spastic movements, and coma.

Food Interaction

  • Take with food. Food reduces irritation.

2-Methoxytrimeprazine Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.



Patients should be advised to avoid alcohol during phenothiazine therapy.

2-Methoxytrimeprazine Disease Interaction

Major: dementia

Elimination Route

2-Methoxytrimeprazine has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.

Half Life

Approximately 20 hours.

Innovators Monograph

You find simplified version here 2-Methoxytrimeprazine

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http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0004150
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http://www.genome.jp/dbget-bin/www_bget?drug:D00403
http://www.genome.jp/dbget-bin/www_bget?cpd:C07192
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=72287
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507223
https://www.chemspider.com/Chemical-Structure.65239.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50418049
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6852
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6838
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1764
https://zinc.docking.org/substances/ZINC000000020246
http://www.pharmgkb.org/drug/PA164743234
https://en.wikipedia.org/wiki/Levomepromazine
*** Taking medicines without doctor's advice can cause long-term problems.
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