2-Methoxyestradiol-17beta

2-Methoxyestradiol-17beta Uses, Dosage, Side Effects, Food Interaction and all others data.

2-Methoxyestradiol-17beta (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.

2-Methoxyestradiol-17beta belongs to the family of drugs called angiogenesis inhibitors. It also acts as a vasodilator.

Trade Name 2-Methoxyestradiol-17beta
Generic 2-Methoxyestradiol
2-Methoxyestradiol Other Names 2-ME2, 2-Methoxyestradiol-17beta, 2ME2
Type
Formula C19H26O3
Weight Average: 302.4079
Monoisotopic: 302.188194698
Protein binding

2ME2 was found to bind in decreasing order to plasma>albumin>alpha1-acid glycoprotein>sex-hormone-binding globulin. Plasma concentration-time profiles of total 2ME2 and unbound 2ME2 concentrations in a patient with cancer receiving 2ME2 as a single oral dose were parallel to each other. Thus, indicating that plasma protein binding is not an important consideration in pharmacokinetic monitoring of 2ME2.

Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
2-Methoxyestradiol-17beta
2-Methoxyestradiol-17beta

Uses

For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis.

How 2-Methoxyestradiol-17beta works

2-Methoxyestradiol-17beta is an angiogenesis inhibitor, and has been shown to attack both tumor cells and their blood supply in preclinical testing. 2-methoxyestradiol is a naturally occurring estrogen metabolite but has no undesired estrogenic activity.

Innovators Monograph

You find simplified version here 2-Methoxyestradiol-17beta

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