10a-labda-8(20)

10a-labda-8(20) Uses, Dosage, Side Effects, Food Interaction and all others data.

10a-labda-8(20) (HMPL-004) is a botanical product extracted from a herb that occurs naturally in China. The herb has an extensive history of use in TCM for the treatment of upper respiratory tract infections and other inflammatory and infectious diseases.

Trade Name 10a-labda-8(20)
Generic Andrographolide
Andrographolide Other Names 3α,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid γ-Lactone
Type
Formula C20H30O5
Weight Average: 350.455
Monoisotopic: 350.209324066
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
10a-labda-8(20)
10a-labda-8(20)

Uses

Investigated for use/treatment in ulcerative colitis.

How 10a-labda-8(20) works

HMPL-004 acts on multiple cellular targets in the inflammatory signal transduction pathways resulting in suppressed inflammation cytokine expression including TNF-α, IL-1β and IL-6. HMPL-004 was demonstrated to inhibit TNF-α and IL-1β production in cell-based assays. HMPL-004 is also able to inhibit NF-kB activation. NF-kB is a family of transcriptional factors that regulate a wide spectrum of genes critically involved in host defence and inflammation. The mechanism of action of HMPL-004 was further supported in laboratory IBD animal models. Treatment of IBD rats with HMPL-004 caused a significant drop in plasma cytokine concentrations, including TNF-α and IL-1β.

Innovators Monograph

You find simplified version here 10a-labda-8(20)

*** Taking medicines without doctor's advice can cause long-term problems.
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