1-Methylphenobarbital

1-Methylphenobarbital Uses, Dosage, Side Effects, Food Interaction and all others data.

A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.

1-Methylphenobarbital, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.

Trade Name 1-Methylphenobarbital
Generic Methylphenobarbital
Methylphenobarbital Other Names 1-Methylphenobarbital, Enphenemal, Mephobarbital, Mephobarbitone, Méthylphénobarbital, Methylphenobarbital, Methylphenobarbitalum, Methylphenobarbitone, Metilfenobarbital, Metilfenobarbitale, N-Methylphenobarbital
Type
Formula C13H14N2O3
Weight Average: 246.2619
Monoisotopic: 246.100442324
Protein binding

70-76%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
1-Methylphenobarbital
1-Methylphenobarbital

Uses

For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy.

How 1-Methylphenobarbital works

1-Methylphenobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Food Interaction

No interactions found.

Elimination Route

Approximately 50% of an oral dose of mephobarbital is absorbed from the gastrointestinal tract.

Half Life

34 (range 11-67) hours

Innovators Monograph

You find simplified version here 1-Methylphenobarbital

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0000292
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http://classyfire.wishartlab.com/tax_nodes/C0002389
http://classyfire.wishartlab.com/tax_nodes/C0002279
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http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6758
http://www.hmdb.ca/metabolites/HMDB0014987
http://www.genome.jp/dbget-bin/www_bget?drug:D00700
http://www.genome.jp/dbget-bin/www_bget?cpd:C07829
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8271
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505197
https://www.chemspider.com/Chemical-Structure.7972.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6758
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6758
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL45029
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000680
http://www.pharmgkb.org/drug/PA450374
http://www.rxlist.com/cgi/generic2/mephobarbital.htm
https://en.wikipedia.org/wiki/Methylphenobarbital
*** Taking medicines without doctor's advice can cause long-term problems.
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