1-Metaraminol

1-Metaraminol Uses, Dosage, Side Effects, Food Interaction and all others data.

An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension.

1-Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. 1-Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. 1-Metaraminol acts on both α1-adrenergic receptors but appears to have no effect on β-adrenergic receptors. It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels.

1-Metaraminol
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Trade Name	1-Metaraminol
Availability	Discontinued
Generic	Metaraminol
Metaraminol Other Names	1-Metaraminol, Hydroxynorephedrine, L-Metaraminol, m-Hydroxy norephedrine, m-Hydroxyphenylpropanolamine, m-Hydroxypropadrine, Metaraminol, Métaraminol, Metaraminolum
Type
Formula	C₉H₁₃NO₂
Weight	Average: 167.205 Monoisotopic: 167.094628665
Protein binding	Approximately 45%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage

How 1-Metaraminol works

1-Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). Its effect is thought to be associated with the inhibition of adenyl cyclase which leads to an inhibition of the production of cAMP. Another effect of 1-Metaraminol is that it releases norepinephrine from its storage sites indirectly.