Danfree Scalp Shampoo

Danfree Scalp Shampoo is manufactured by Eskayef Bangladesh Ltd. Danfree Scalp Shampoo contains 2% Ketoconazole. It is Drugs for subcutaneous and systemic mycoses class drug.

Danfree interferes with biosynthesis of triglycerides and phopholipids by blocking fungal CYP450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.


Treatment of superficial and deep mycoses:

  • Infections of the skin, hair and nails by dermatophytes and/or yeasts (dermatomycosis, onychomycosis, perionyxis, pityriasis versicolor, chronic mucocutaneous candidiasis etc.) especially when topical treatment is difficult or not very effective, owing to involvement of large skin surfaces or to lesions affecting deeper dermal layers, nails and hairs
  • Yeast infection of the mouth (oral thrush, perleche) and the gastrointestinal tract
  • Vaginal candidiasis, especially chronic recurrent cases or cases responding poorly to topcial treatment
  • Systemic mycotic infections such as systemic candidiasis, paracoccidioidomycosis, histoplasmosis, coccidioidomycosis etc.

Maintenance treatment to prevent recurrence in systemic mycotic infections and in chronic mucocutaneous candidiasis.Prophylactic treatment to prevent mycotic infection in patients with reduced host defenses, e.g., patients with cancer, organ transplant and burns.

Brand Name: Danfree
Generic: Ketoconazole
Weight: 2%
Type: Scalp Shampoo
Therapeutic Class: Drugs for subcutaneous and systemic mycoses
Manufacturer: Eskayef Bangladesh Ltd
Price: 0.00
Last Updated: November 21, 2020 at 6:15 pm


Danfree contains Ketoconazole 2%. Danfree Dosage:


Fungal infections:

  • Adult: 200 mg once daily; may increase to 400 mg once daily if clinical response is insufficient. Continue treatment until symptoms have cleared and cultures have become negative.
  • Child: ≥2 yr 3.3-6.6 mg/kg once daily. Treatment duration: 1-2 wk for candidiasis; at least 4 wk in recalcitrant dermatophyte infections and up to 6 mth for other systemic mycoses.
  • Elderly: No dosage adjustment needed.

Topical (Adult)-

Pityriasis versicolor, Skin fungal infections: 

  • As 2% cream: Apply 1-2 times daily to cover affected and surrounding area until at least a few days after disappearance of symptoms.
  • As 2% shampoo: Apply on scalp once daily for up to 5 days. For prophylaxis: As 2% shampoo, use once daily for a max of 3 days before exposure to sunlight.

Seborrhoeic dermatitis: 

  • As 2% foam: Apply to the affected area bid for 4 wk.
  • As 1 or 2% shampoo: Apply on the scalp twice wkly for 2-4 wk. For prophylaxis: As 2% shampoo, use once every 1-2 wk.

Duration of Treatment

  • Pityriasis versicolor: 1 to 6 weeks
  • Dermatomycoses: 2 to 8 weeks
  • Onychomycoses: 1 to 12 months
  • Mycoses of hair and scalp: 1 to 2 months
  • Chronic mucocutaneous candidiasis : 1 to 12 months
  • Oral mycoses: 5 to 10 days
  • Systemic candidiasis: 1 to 2 months
  • Paracoccidioidomycosis,histoplasmosis
  • and other systemic mycosis: 1 month to 2 years

Side Effects

Danfree is very well tolerated. Nausea and itching may occasionally occur. In some patients, an idosyncratic liver reaction may occur (incidence 1 : 10,000).


Predisposition to adrenocortical insufficiency. Admin with acidic drink in patients with achlorhydria. Pregnancy and lactation.



Reduced absorption with antimuscarinics, antacids, H2-blockers, PPIs and sucralfate. Reduced plasma concentrations with rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. May also reduce concentrations of isoniazid and rifampicin. May reduce efficacy of oral contraceptives. May increase serum levels of CYP3A4 substrates e.g. digoxin, oral anticoagulants, sildenafil, tacrolimus.

Pregnancy Lactation use

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.


Hypersensitivity; preexisting liver disease. Concurrent use with CYP3A4 substrates e.g. HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin), midazolam, triazolam, cisapride, dofetilide, eplerenone, nisoldipine, pimozide, quinidine, terfenadine, astemizole, ergot alkaloids (e.g. ergotamine, dihydroergotamine).

Special Warning

Renal Impairment: Oral: No dosage adjustment needed.

Hepatic Impairment: Oral: Contraindicated.

Acute Overdose


Interaction with other Medicine


Storage Condition

Store between 15-25° C. Protect from moisture and light.