Avomit Oral Suspension

Avomit Oral Suspension is manufactured by Chemist Laboratories Limited. Avomit Oral Suspension contains 5 mg/ 5 ml Domperidone Maleate. It is Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs class drug.

Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Uses

Stimulation of gut motility in-

  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies

Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.

In the prophylactic treatment of migraine.

Brand Name: Avomit
Generic: Domperidone Maleate
Weight: 5 mg/ 5 ml
Type: Oral Suspension
Therapeutic Class: Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Manufacturer: Chemist Laboratories Limited
Price: 39.20
Last Updated: November 21, 2020 at 6:15 pm

Dosage

Avomit contains Domperidone Maleate 5 mg/ 5 ml. Avomit Dosage:

Adults: 10 - 20 mg every 4 - 8 hours daily

Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Domperidone tablet and suspension should be taken 15 - 30 minutes before a meal.  For acute nausea and vomiting, maximum period of treatment is 12 weeks.

 

Side Effects

Domperidone may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Precaution

Domperidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.

Avomit

Interaction

Domperidone may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Domperidone on gastrointestinal function.

Pregnancy Lactation use

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy. 

Use in lactation: Domperidone may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Contraindication

Domperidone is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Special Warning

 

Acute Overdose

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

Interaction with other Medicine

 

Storage Condition

Store in a cool dry place protected from light. Keep out of reach of children.

FAQ

What is Avomit used for?

Avomit (Domperidone) is an anti-sickness medicine. It helps you to stop feeling or being sick (nausea or vomiting). It can also be used to treat stomach pain if you're having end of life care (palliative care). Avomit is sometimes used to increase milk supply.

What are the side effects of Avomit?

The possible side effects of Avomit

  • diarrhea.
  • headache.
  • drowsiness.
  • dry mouth.
  • stomach cramps.
  • discomfort and fullness of the breasts; this is an expected side effect for the purpose of increasing your breast milk.
  • rash or hives.

What is the difference between Domperidone and Domperidone Maleate?

A dopamine antagonist, domperidone is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The maleate salt is used in tablet preparations, while the free base is used in oral suspensions.

Who should not take Avomit?

Avomit products are contraindicated in patients with severe hepatic impairment, conditions where cardiac conduction is, or could be, impaired or where there is underlying cardiac disease such as congestive heart failure, and when co-administered with QT-prolonging medicines or potent CYP3A4 inhibitors.

Is Avomit safe to take?

Information for consumers and caregivers. For most people, taking Avomit is safe. However, if you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate. Use the lowest dose that works for you and stop as soon as you can.

Is Avomit good for bloating?

Avomit is used for the relief of symptoms of excessive fullness, nausea, stomach bloating and belching occasionally accompanied by stomach discomfort and heartburn after meals. Avomit belongs to a group of medications known as dopamine antagonists. Avomit works by stimulating gut movement.

Is Avomit bad for heart?

Avomit may be associated with an increased risk of QT interval prolongation, serious ventricular arrhythmia or sudden cardiac death. The risk may be higher in patients older than 60 years or at total daily doses of more than 30mg.

Does Avomit make your boobs bigger?

Avomit works to raise levels of prolactin, which helps increase the production of breast milk. Avomit is usually started at a dose of 10 milligrams (one tablet) three times a day.

Can I take Avomit after meal?

Take your doses about half an hour before meals. If you take Avomit after a meal, it will still work, but it may take longer to have an effect. Avomit should be taken for a short period of time only. Your treatment will last no longer than seven days.

Does Avomit increase blood pressure?

Avomit increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.

Is Avomit a laxative?

Avomit is the only medication that is a true prokinetic with a low percentage of side effects that is useful in the treatment of certain GI conditions, including gastroparesis and other motility disorders.

Can I take Avomit on an empty stomach?

The pharmacist may instruct you to take each does 30 minutes before eating, but that is because of its usual use for digestive problems. Taking Avomit on an empty stomach does allow it to be better absorbed, but it is not necessary to do this for it to work to increase breastmilk production.

How does Avomit work in the body?

Avomit works by increasing the movement of food through the stomach and the digestive tract more quickly and in this way reduces the feeling of bloating, or fullness and indigestion. It also works by blocking the action of a chemical in your brain which causes the feeling of nausea and vomiting.

Is Avomit good for gastritis?

Avomit has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment. Avomit is a kind of drug to strengthen gastric motility.

Where is Avomit absorbed?

Avomit is absorbed from the GI tract but has an oral bioavailability of only 20% in the dog. This is presumably due to a high first-pass effect. The drug is highly protein bound (93%). Peak levels occur about 2 h after dosing.

Can Avomit cure gastroparesis?

The majority of patients remaining on treatment experienced an improvement in symptoms of gastroparesis, particularly postprandial fullness, nausea, vomiting, and stomach fullness. Thus, Avomit treatment is beneficial for many patients with symptoms of gastroparesis.

How do I know if Avomit is working?

Most breastfeeding mothers see an improvement in milk supply usually starting after the first week. If you are regularly expressing and taking the medication, the milk supply should improve within 3-4 weeks.

What is the half life of Avomit?

In studies with severe renal insufficiency (serum creatinine > 6 mg/100 mL, i.e., > 0.6 mmol/L) the half-life of Avomit is increased from 7.4 to 20.8 hours, but plasma drug levels are lower than in subjects with normal renal function.

Is Avomit a laxative?

Avomit has limited ability to cross the blood-brain barrier and therefore acts primarily as a peripheral antagonist. Thus, in contrast to metoclopramide, Avomit rarely causes dystonic or extrapyramidal symptoms and it may increase prolactin levels and occasionally female patients may develop galactorrhea.

Is Avomit safe for child?

Avomit no longer approved for use in children due to a lack of efficacy. The use of Avomit in newborns, infants, children (under 12) and adolescents weighing less than 35kg is no longer approved at European level.

Is Avomit a hormone?

Avomit is a drug which has, as a side effect, the increased production of the hormone prolactin. Prolactin is the hormone which stimulates the cells in the mother's breast to produce milk.