ATP Tablet is manufactured by General Pharmaceuticals Ltd. ATP Tablet contains 500 mg Paracetamol. It is Non opioid analgesics class drug.
ATP exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
ATP (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
ATP is used for:
- Fever,common cold and influenza.
- Headache,toothache, earache, bodyache, myalgia, dysmenorrhoea, neuralgia and sprains.
- Pain of colic, back pain, post-operative pain, postpartum pain, chronic pain of cancer, inflammatory pain, and post-vaccination pain and fever of children.
- Rheumatism and osteoarthritic pain & stiffness of joints in fingers, hips, knees, wrists, elbows, feet, ankles and top & bottom of the spine.
|Therapeutic Class:||Non opioid analgesics|
|Manufacturer:||General Pharmaceuticals Ltd|
|Last Updated:||June 9, 2021 at 5:08 pm|
Table Of contents
ATP contains Paracetamol 500 mg. ATP Dosage:
- Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
- Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.
Extended Release Tablet:
- Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crushed.
- Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
- 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
- 1-5 years: 1 -2 teaspoonful 3 to 4 times daily.
- 6-12 years: 2-A teaspoonful 3 to 4 times daily.
- Adults: 4-8 teaspoonful 3 to 4 times daily.
- Children 3-12 months: 60-120 mg,4 times daily.
- Children 1-5 years: 125-250 mg 4 times daily.
- Children 6-12 years: 250-500 mg 4 times daily.
- Adults & children over 12 years: 0.5-1 gm 4 times daily.
- Children Upto 3 months: 0.5 ml (40 mg)
- 4 to 11 months: 1.0 ml (80 mg)
- 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.
Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.
ATP should be given with caution to patients with impaired kidney or liver function. ATP should be given with care to patients taking other drugs that affect the liver.
May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use. Accelerated absorption with metoclopramide and domperidone. May increase serum levels with probenecid. May increase serum levels of chloramphenicol. May reduce absorption with colestyramine within 1 hr of admin. May cause severe hypothermia with phenothiazine.
Pregnancy Lactation use
ATP is safe in all stage of pregnancy and lactation.
ATP is contraindicated in patients with severe renal function impairment and hepatic disease (Viral Hepatitis). Contraindicated in known sensitivity to ATP
Interaction with other Medicine
Tablet, Syrup & Suspension: Keep in a cool & dry place, protected from light and moisture.Suppository: Store below 25° C. Keep all medicines out of the reach of children.
What is ATP?
ATP is a common painkiller used to treat aches and pain. It can also be used to reduce a high temperature. It's available combined with other painkillers and anti-sickness medicines. It's also an ingredient in a wide range of cold and flu remedies.
What are side effects of ATP?
- Skin rash that may include itchy, red, swollen, blistered or peeling skin.
- Tightness in the chest or throat.
- Trouble breathing or talking.
- Mouth, face, lips, tongue or throat start swelling.
How safe is ATP?
ATP is known to cause liver failure in overdose, but it also causes liver failure in people taking standard doses for pain relief. The risk is only about one in a million, but it is a risk. All these different risks stack up.
What are the types of ATP?
Types of ATP
- tablets or caplets.
- liquid – usually for children.
- soluble tablets (tablets that dissolve in water to make a drink)
- suppositories (capsules inserted into the back passage)
- an injection given into a vein – normally only used in hospital.
What happens if you take ATP for no reason?
Even taking one or two more tablets than recommended can cause serious liver damage and possibly death. ATP overdose is one of the leading causes of liver failure.
Why is ATP bad for your liver?
ATP itself is not toxic, but in large amounts it overwhelms the body's ability to process it safely. This can lead to build up of a toxic metabolite (or break-down product), which binds to liver cells, causing these cells to die.
What are the indications of ATP?
This ATP is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
What happens if I take ATP on an empty stomach?
Ibuprofen, aspirin and other NSAIDs (non-steroidal anti-inflammatory drugs) can irritate the stomach lining, so it is best to take them with food, or a glass of milk. ATP doesn't irritate the stomach lining so it won't matter if you haven't eaten.
Can ATP help you sleep?
A successful result is one where the pain is reduced by half or more, or where they have no or only mild pain. That result delivers not just on pain, but also improves sleep, depression, quality of life, work, and the ability to get on with life.
How is ATP eliminated from the body?
ATP is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 30 minutes to 2 hours after ingestion. It is metabolised in the liver (90-95%) and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged ATP.
Is ATP is safe during pregnancy?
ATP is the first choice of painkiller if you're pregnant. ATP been taken by many pregnant women with no harmful effects in the mother or baby.
Is ATP is safe during breastfeeding?
ATP is the first choice of painkiller if you're breastfeeding women. It's been taken by many breastfeeding women with no harmful effects in the mother or baby.
How does ATP work?
ATP seems to work by blocking chemical messengers in the brain that tell us we have pain. It also reduces fever by affecting the chemical messengers in an area of the brain that regulates body temperature.
When will I feel better after taking ATP?
ATP takes up to an hour to work. It keeps on working for about 5 hours.
Can I take ATP for a long time?
It's safe to take ATP regularly for many years as long as you don't take more than the recommended dosage.
Will ATP affect my fertility?
There's no firm evidence to suggest that taking ATP will reduce fertility in either men or women.
Will ATP affect my contraception?
ATP doesn't affect any type of contraception including the contraceptive pill or emergency contraception.
Can I drink alcohol with ATP?
Drinking a small amount of alcohol while taking ATP is usually safe. Try to keep to the recommended guidelines of no more than 14 units of alcohol a week. A standard glass of wine (175ml) is 2 units. A pint of lager or beer is usually 2 to 3 units of alcohol.
Is there any food or drink I need to avoid when taking ATP?
You can eat and drink normally while taking ATP. You can safely take ATP (but not ibuprofen) on an empty stomach.