Arolak Tablet

Arolak Tablet is manufactured by Ambee Pharmaceuticals Ltd. Arolak Tablet contains 10 mg Ketorolac Tromethamine (Oral / Injection / Nasal). It is Drugs used for Rheumatoid Arthritis, Non-Opioid Analgesics class drug.

Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) chemically related to indomethacin and tolmetin. Ketorolac tromethamine is a racemic mixture of [-]S- and [+]R-enantiomeric forms, with the S-form having analgesic activity. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis leading to decreased formation of precursors of prostaglandins and thromboxanes from arachidonic acid. The resultant reduction in prostaglandin synthesis and activity may be at least partially responsible for many of the adverse, as well as the therapeutic, effects of these medications. Analgesia is probably produced via a peripheral action in which blockade of pain impulse generation results from decreased prostaglandin activity. However, inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation may also contribute to the analgesic effect. In terms of the ophthalmic applications of ketorolac - ocular administration of ketorolac reduces prostaglandin E2 levels in aqueous humor, secondary to inhibition of prostaglandin biosynthesis.

Uses

Ketorolac injections and tablets are used for the short-term management of moderate to severe acute post-operative pain.

Brand Name: Arolak
Generic: Ketorolac Tromethamine (Oral / Injection / Nasal)
Weight: 10 mg
Type: Tablet
Therapeutic Class: Drugs used for Rheumatoid Arthritis, Non-Opioid Analgesics
Manufacturer: Ambee Pharmaceuticals Ltd
Price: 14.06
Last Updated: November 22, 2020 at 6:15 pm

Dosage

Arolak contains Ketorolac Tromethamine (Oral / Injection / Nasal) 10 mg. Arolak Dosage:

Ketorolac Tablet-

Ketorolac Tablet is recommended for short-term use only (up to 7 days) and are not recommended for chronic use. 10 mg every 4 to 6 hours as required. Doses exceeding 40 mg/day are not recommended. For patients receiving parenteral Ketorolac tromethamine, and who are converted to Ketorolac tromethamine oral tablets, the total combined daily dose should not exceed 90 mg (60 mg for the elderly, renally impaired patients and patients less than 50 kg) and the oral component should not exceed 40 mg on the day the change of formulation is made. Patients should be converted to oral treatment as soon as possible.

Ketorolac injection-

Ketorolac injection may be used as a single or multiple doses, on a regular or when necessary schedule for the management of moderately severe, acute pain that requires analgesia at the opioid level, usually in a postoperative setting. When administering Ketorolac injection, the IV bolus must be given over no less than 15 seconds. The IM administration should be given slowly and deeply into the muscle. The analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM. Duration of analgesic effect is usually 4 to 6 hours. Single-Dose Treatment: The following regimen should be limited to single administration use only.

IM Dosing (Adult):

  • Patients <65 years of age: One dose of 60 mg.
  • Patients >65 years of age, renally impaired and/or less than 50 kg of body weight: One dose of 30 mg.

IV Dosing (Adult):

  • Patients <65 years of age: One dose of 30 mg.
  • Patients >65 years of age, renally impaired and/or less than 50 kg of body weight: One dose of 15 mg.

IV or IM Dosing (2 to 16 years of age):

  • IM Dosing: One dose of 1 mg/kg up to a maximum of 30 mg.
  • IV Dosing: One dose of 0.5 mg/kg up to a maximum of 15 mg.

Multiple-Dose Treatment (IV or IM):

  • Patients <65 years of age: The recommended dose is 30 mg Ketorolac injection every 6 hours. The maximum daily dose should not exceed 120 mg. Patients >65 years of age, renally impaired patients and patients less than 50 kg: The recommended dose is 15 mg Ketorolac injection every 6 hours. The maximum daily dose for these populations should not exceed 60 mg. For breakthrough pain, do not increase the dose or the frequency of Ketorolac Tromethamine.
  • Conversion from Parenteral to Oral Therapy: Ketorolac tablets may be used either as monotherapy or as follow-on therapy to parenteral Ketorolac. When Ketorolac tablets are used as a follow-on therapy to parenteral Ketorolac, the total combined daily dose of ketorolac (oral + parenteral) should not exceed 120 mg in younger adult patients or 60 mg in elderly patients on the day the change of formulation is made. On subsequent days, oral dosing should not exceed the recommended daily maximum of 40 mg. Ketorolac IM should be replaced by Ketorolac tablet as soon as feasible. The total duration of combined parenteral and oral treatment should not exceed 5 days.

Ketorolac Nasal spray-

  • Adults weighing 50 kg or more: 31.5 mg or 2 spray in each nostril every 6 to 8 hours. Your doctor may adjust your dose if needed. However, the dose is not more than 126 mg (a total of 8 sprays) per day.
  • Older adults and adults weighing less than 50 kg: 15.75 mg or 1 spray in only one nostril every 6 to 8 hours. However, the dose is usually not more than 63 mg (a total of 4 sprays) per day.
  • Children: Use and dose must be determined by your doctor.

 

Side Effects

Commonly occurring side-effects are nausea, vomiting, gastro intestinal bleeding,melaena, peptic ulcer, pancreatitis, anxiety, drowsiness, dizziness, headache, hallucinations,excessive thirst, inability to concentrate, insomnia, malaise, fatigue, pruritus, urticaria, skin photosensitivity, Lyell's syndrome, Stevens-Johnson syndrome, flushing, bradycardia, hypertension, palpitations, chest pain, infertility in female, dyspnoea, asthma, pulmonary oedema, fever, injection site pain.

Precaution

Patients over the age of 65 years may be at a greater risk of experiencing adverse events than younger patients. Ketorolac tromethamine can cause gastro-intestinal irritation, ulcers or bleeding in patients with or without a history of previous symptoms. Bronchospasm may be precipitated in patients with a history of asthma. Since ketorolac tromethamine and its metabolites are excreted primarily by the kidney, patients with moderate to severe impairment of renal function (serum creatinine greater than 160 micromol/l) should not receive. Fluid retention and oedema have been reported with the use of Ketorolac tromethamine.

Arolak

Interaction

Ketorolac tromethamine should not be used with other NSAIDs or in patients receiving aspirin because of the potential for additive side effects. Care should be taken when administering Ketorolac tromethamine with anti-coag ulants since co-administration may cause an enhanced anti-coagulant effect. Ketorolac tromethamine and other non-steroidal anti-inflammatory drugs can reduce the anti hypertensive effect of beta-blockers and may increase the risk of renal impairment when administered concurrently with ACE inhibitors, particularly in volume depleted patients. Caution is advised when methotrexate is administered concurrently, since some prostaglandin  synthesis inhibiting drugs have been reported to reduce the clearance of methotrexate, and thus possibly enhance its toxicity. Probenecid should not be administered concurrently with ketorolac tromethamine because of increases in ketorolac plasma level and half-life.

Pregnancy Lactation use

Safety in human pregnancy has not been established. Ketorolac has been detected in human milk at low levels. Ketorolac is therefore contraindicated during pregnancy, labour or delivery, or in mothers who are breast feeding.

Contraindication

Ketorolac Tromethamine is contraindicated in patients with known hypersensitivity to NSAIDs and any of the components of Ketorolac Tromethamine. Moreover, the patient with the history of asthma, nasal polyp, angioedema, peptic ulcer and bleeding, bleeding disorders are contraindicated for this drug.

Special Warning

 

Acute Overdose

Symptoms: Abdominal pain, nausea, vomiting, hyperventilation, peptic ulceration, erosive gastritis and renal dysfunction.

Management: Symptomatic and supportive treatment. Consider gastric lavage or admin of activated charcoal within 1 hr of ingestion.

Interaction with other Medicine

 

Storage Condition

Tablet & injection should be store in a cool & dry place, protect from light & moisture.

FAQ

What is Arolak used for?

Arolak is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat moderately severe pain and inflammation, usually after surgery. Arolak works by blocking the production of prostaglandins, compounds that cause pain, fever, and inflammation.

Why Arolak use only for 5 days?

Parenteral Arolak (ketorolac tromethamine) has been effectively used to treat postoperative pain for several decades. However, its use is limited to a 5-day treatment duration due to an increased risk of gastrointestinal (GI) bleeding.

Is Arolak stronger than ibuprofen?

Intravenous Arolak given at the conclusion of surgery was more effective than either oral acetaminophen or oral ibuprofen given 30 to 45 minutes after strabismus surgery in controlling postoperative pain. Pain relief was achieved earlier by intravenous delivery than by oral agents.

Is Arolak stronger than tramadol?

A study in India compared Arolak to tramadol for post-op pain after maxillofacial surgery in 50 adults. Both drugs were given IM. Both drugs caused a significant decrease in pain, but tramadol resulted in better pain control than Arolak at every hour, and was better tolerated.

How long does it take for Arolak to kick in?

It starts working quickly (about 15 minutes after administration) and can last up to 6 hours. It's often prescribed for post-surgery pain and acute migraines, but also for chronic migraines when other treatments haven't worked.

Who should not take Arolak?

chronic kidney disease stage 4 (severe) chronic kidney disease stage 5 (failure) kidney disease with likely reduction in kidney function. aspirin exacerbated respiratory disease.

Is Arolak stronger than naproxen?

Arolak is not used for minor or chronic painful conditions. Other NSAIDs include naproxen (Aleve, Naprosyn) and ibuprofen (Advil, Motrin), but Arolak is better than other NSAIDs in reducing pain from both inflammatory and non-inflammatory causes.

Can I get addicted to Arolak?

Arolak is not addictive, but it's a very strong NSAID and can lead to serious side effects. You also shouldn't take it for long periods of time.

Does Arolak cause drowsiness?

Arolak may cause some people to become dizzy or drowsy. If either of these side effects occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert. Serious side effects can occur during treatment with this medicine.

Is Arolak good for back pain?

Based on comparable efficacy and a superior adverse event profile, Arolak was preferable to acetaminophen with codeine for the treatment of acute low back pain in the ED.

What is Arolak equivalent to?

Clinical evidence from other settings has shown that Arolak (ketorolac) and morphine are equivalent in relieving pain, but there is a distinct benefit favoring Arolak (ketorolac) in terms of side effects.

Is Arolak 10 mg a controlled substance?

Arolak is used in the treatment of postoperative pain; pain and belongs to the drug class Nonsteroidal anti-inflammatory drugs. Risk cannot be ruled out during pregnancy. Arolak 10 mg is not a controlled substance under the Controlled Substances Act (CSA).

Is Arolak anti-inflammatory?

Arolak, like other NSAIDs, has analgesic, anti-inflammatory, and antipyretic properties. Unlike morphine or meperidine, Arolak (ketorolac) does not bind to opioid receptors and is not a centrally acting agent. Administered intramuscularly, peak plasma levels are reached in 45 to 50 minutes.

Does Arolak work for pain?

Arolak (ketorolac tromethamine) is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat moderately severe pain and inflammation, usually after surgery. Arolak works by blocking the production of prostaglandins, compounds that cause pain, fever, and inflammation.

Does Arolak have a black box warning?

Arolak is contraindicated in patients currently receiving aspirin and/or NSAIDs because of cumulative risk of inducing serious NSAID-related side effects. Please see BLACK BOX WARNINGS for additional precautions.

Is Arolak the same as tramadol?

Arolak and tramadol belong to different drug classes. Arolak is a nonsteroidal anti-inflammatory drug (NSAID) and tramadol is a pain reliever (analgesic) that acts similar to narcotics.

What are the side effects of Arolak?

Side effects of Arolak include:

  • Headache
  • Drowsiness
  • Indigestion
  • Stomach or abdominal pain
  • Nausea
  • Diarrhea
  • Dizziness
  • Itching
  • Swelling (edema)
  • Increased blood urea nitrogen (BUN)
  • Constipation
  • Purpura
  • Increased serum creatinine
  • Drowsiness
  • High blood pressure (hypertension)

What drugs does Arolak interact with?

Interaction reports for Arolak and the medicines listed below.

  • Benadryl (diphenhydramine)
  • Benadryl (diphenhydramine)
  • Combivent (albuterol / ipratropium)
  • Combivent (albuterol / ipratropium)
  • Cymbalta (duloxetine)
  • Cymbalta (duloxetine)
  • Flexeril (cyclobenzaprine)
  • Flexeril (cyclobenzaprine)
  • Lyrica (pregabalin)
  • Lyrica (pregabalin)
  • Norco (acetaminophen / hydrocodone)
  • Norco (acetaminophen / hydrocodone)
  • Paracetamol (acetaminophen)
  • Paracetamol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Xanax (alprazolam)

Can I drink alcohol while taking Arolak?

Avoid drinking alcohol. It may increase your risk of stomach bleeding. Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms

Where do I inject Arolak?

Arolak is given by injection into a muscle or vein as directed by your doctor. It may be given as a one-time dose or given on a regular schedule. If given on a regular schedule, it is usually injected every 6 hours as needed, or as directed by your doctor. This drug must not be injected into the spine.

Is Arolak bad for heart?

Arolak can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

How many days in a row can take Arolak?

Minor upper gastrointestinal problems, such as dyspepsia, are common and may also occur at any time during NSAID therapy. The incidence and severity of gastrointestinal complications increases with increasing dose of, and duration of treatment with, Arolak. Do not use Arolak for more than five days.

Can I take Arolak and ibuprofen together?

Using Arolak together with ibuprofen is not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

Can Arolak cause weight gain?

If you experience any of the following symptoms, stop using Arolak injection and call your doctor: unexplained weight gain; swelling of the hands, arms, feet, ankles, or lower legs; confusion; or seizures.

What does Arolak do for eyes?

Ophthalmic Arolak is used to treat itchy eyes caused by allergies. It also is used to treat swelling and redness (inflammation) that can occur after cataract surgery. Arolak is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs).

Can Arolak help with nerve pain?

Arolak is not commonly used to treat neuropathic pain, as NSAIDs have limited evidence in the management of neuropathic pain.

What are the benefits of Arolak?

This medication is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever. Arolak should not be used for mild or long-term painful conditions (such as arthritis).

Is Arolak a painkiller?

Arolak is a painkiller medicine.

Is it safe to use Arolak?

Arolak has side effects that can be very dangerous. The risk of having a serious side effect increases with the dose of Arolak and with the length of treatment. Therefore, Arolak should not be used for more than 5 days.

What medicine should not take with Arolak?

Do not take aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) while you are taking Arolak. Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines.

What is Arolak?

Arolak is a non-steroidal anti-inflammatory drug (NSAID). It is used for a short while to treat moderate to severe pain, including pain after surgery. It should not be used for more than 5 days.

How long can I use Arolak eye drops?

Adults and children 3 years of age and older

  • Use one drop in the affected eye(s) 4 times a day for up to 4 days after the surgery. 
  • Children younger than 3 years of age—Use and dose must be determined by your doctor.

How long should I use Arolak after cataract surgery?

For cataract surgery you will begin using the eye drops 1 day before surgery and continue for up to 2 weeks afterward. For corneal refractive surgery the usual dosage is 4 times daily for up to 4 days after surgery. Do not use Arolak ophthalmic while you are wearing contact lenses.

How long does Arolak stay in my body?

The average elimination half-life of Arolak is 5 to 6 hours. This is the time it takes for your body to reduce the plasma levels by half.