Arbecin Injection

Arbecin Injection is manufactured by Renata Limited. Arbecin Injection contains 100 mcg/ml Carbetocin. It is Drugs acting on the Uterus class drug.

Arbecin is a long-acting synthetic octapeptide analogue of oxytocin. It acts as an agonist at peripheral oxytocin receptors, particularly in the myometrium of uterus.

Uses

Arbecin is used for the prevention of uterine atony and postpartum haemorrhage (excessive bleeding) following delivery of the infant by elective caesarean section under epidural or spinal anaesthesia.

Brand Name: Arbecin
Generic: Carbetocin
Weight: 100 mcg/ml
Type: Injection
Therapeutic Class: Drugs acting on the Uterus
Manufacturer: Renata Limited
Price: 210.00
Last Updated: November 22, 2020 at 6:15 pm

Dosage

Arbecin contains Carbetocin 100 mcg/ml. Arbecin Dosage:

A single intravenous dose of 100 mcg (1 ml) of Carbate (carbetocin injection) is administered by bolus injection, slowly over 1 minute, only when infant delivery has been completed by caesarean section under epidural or spinal anaesthesia.Carbate is to be used as a single dose only.

 

Side Effects

10-40% of patients experienced nausea, vomiting, abdominal pain, itching skin, increased body temperature, trembling and weakness. Infrequent adverse events (1-5% of patients) included back pain, dizziness, metallic taste, anaemia, sweating, chest pain, dyspnoea, chills, tachycardia and anxiety.

Precaution

In patients who may not have an adequate uterine contraction after a single injection of carbetocin, more aggressive treatment with additional doses of oxytocin or ergometrine is warranted.As carbetocin is closely related in structure to oxytocin, hyponatraemia may occur.Arbecin should be used cautiously in the presence of epilepsy, migraine, asthma or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system.Patients with eclampsia and pre-eclampsia should be monitored for changes in blood pressure.Arbecin is not recommended for use in elderly patients.

Arbecin

Interaction

No specific drug interactions have been reported with carbetocin.

Pregnancy Lactation use

Use of carbetocin injection is contraindicated during pregnancy.Use in lactationSmall amounts of carbetocin has been shown to cross over from plasma into the breast milk of nursing women. The small amount of carbetocin ingested by infant would not be expected to present a significant safety concern.

Contraindication

Do not administer before delivery. Vascular disease esp coronary artery disease; hepatic or renal disease.

Special Warning

Pediatrics:No information is available on the relationship of age to the effects of carbetocin in pediatric patients. Safety and efficacy have not been established.

Acute Overdose

Overdosage of carbetocin can be expected to produce enhanced pharmacological effects associated with uterine hyperactivity and pain. Treatment consists of symptomatic and supportive management.

Interaction with other Medicine

 

Storage Condition

Store at 2-8°C. Do not freeze. Keep away from light. Once the ampoule has been opened, the product should be used immediately.