Arb Tablet

Arb Tablet is manufactured by Square Pharmaceuticals Ltd. Arb Tablet contains 16 mg Candesartan Cilexetil. It is Angiotensin-ll receptor blocker class drug.

Arb is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastro-intestinal tract. Candesartan is angiotensin II receptor (type AT1) antagonist. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).

Uses

Arb is used for hypertension, heart failure with impaired left ventricular systolic function.

Brand Name: Arb
Generic: Candesartan Cilexetil
Weight: 16 mg
Type: Tablet
Therapeutic Class: Angiotensin-ll receptor blocker
Manufacturer: Square Pharmaceuticals Ltd
Price: 14.10
Last Updated: November 19, 2020 at 6:15 pm

Dosage

Arb contains Candesartan Cilexetil 16 mg. Arb Dosage:

Hypertention: initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily.

Heart failure: initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose.

 

Side Effects

Side-effects are usually mild. Symptomatic hypotension including dizziness may occur, particularly in patients with intravascular volume depletion (e.g. those taking high dose diuretics). Hyperkalemia occurs occassionally; angioedema has also been reported with some angiotension II receptor antagonist. Also vertigo, headache; rarely hepatitis, blood disorders, hyponatraemia, back pain, arthralgia, myalgia, rash, urticaria, pruritous.

Precaution

Candesartan should be used with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertropic cardiomyopathy. Monitoring of plasma-potassium concentration is advised, particularly in the elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.

Arb

Interaction

No significant drug interactions have been reported in studies of Arb given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide and oral contraceptives in healthy volunteers. Because candesartan is not metabolised by the cytochrome P-450 system and has no effects on P-450 enzymes, interactions with drugs that inhibit, or are metabolised by, those enzymes could not be expected.

Pregnancy Lactation use

When pregnancy is detected, Arb should be discontinued as soon as possible. It should be used in lactation.

Contraindication

Hypersensitivity to any component of this product. Pregnancy, breast-feeding, cholestasis.

Special Warning

Use in pediatric: Safety and effectiveness in pediatric patients have not been established.

Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

Store in a cool & dry place. Protect from light and moisture