Apuldon Suppository

Apuldon Suppository is manufactured by Aristopharma Ltd. Apuldon Suppository contains 30 mg Domperidone Maleate. It is Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs class drug.

Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.


Stimulation of gut motility in-

  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies

Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.

In the prophylactic treatment of migraine.

Brand Name: Apuldon
Generic: Domperidone Maleate
Weight: 30 mg
Type: Suppository
Therapeutic Class: Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Manufacturer: Aristopharma Ltd
Price: 12.60
Last Updated: November 21, 2020 at 6:15 pm


Apuldon contains Domperidone Maleate 30 mg. Apuldon Dosage:

Adults: 10 - 20 mg every 4 - 8 hours daily

Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Domperidone tablet and suspension should be taken 15 - 30 minutes before a meal.  For acute nausea and vomiting, maximum period of treatment is 12 weeks.


Side Effects

Domperidone may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.


Domperidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.



Domperidone may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Domperidone on gastrointestinal function.

Pregnancy Lactation use

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy. 

Use in lactation: Domperidone may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.


Domperidone is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Special Warning


Acute Overdose

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

Interaction with other Medicine


Storage Condition

Store in a cool dry place protected from light. Keep out of reach of children.


What is Apuldon used for?

Apuldon (Domperidone) is an anti-sickness medicine. It helps you to stop feeling or being sick (nausea or vomiting). It can also be used to treat stomach pain if you're having end of life care (palliative care). Apuldon is sometimes used to increase milk supply.

What are the side effects of Apuldon?

The possible side effects of Apuldon

  • diarrhea.
  • headache.
  • drowsiness.
  • dry mouth.
  • stomach cramps.
  • discomfort and fullness of the breasts; this is an expected side effect for the purpose of increasing your breast milk.
  • rash or hives.

What is the difference between Domperidone and Domperidone Maleate?

A dopamine antagonist, domperidone is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The maleate salt is used in tablet preparations, while the free base is used in oral suspensions.

Who should not take Apuldon?

Apuldon products are contraindicated in patients with severe hepatic impairment, conditions where cardiac conduction is, or could be, impaired or where there is underlying cardiac disease such as congestive heart failure, and when co-administered with QT-prolonging medicines or potent CYP3A4 inhibitors.

Is Apuldon safe to take?

Information for consumers and caregivers. For most people, taking Apuldon is safe. However, if you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate. Use the lowest dose that works for you and stop as soon as you can.

Is Apuldon good for bloating?

Apuldon is used for the relief of symptoms of excessive fullness, nausea, stomach bloating and belching occasionally accompanied by stomach discomfort and heartburn after meals. Apuldon belongs to a group of medications known as dopamine antagonists. Apuldon works by stimulating gut movement.

Is Apuldon bad for heart?

Apuldon may be associated with an increased risk of QT interval prolongation, serious ventricular arrhythmia or sudden cardiac death. The risk may be higher in patients older than 60 years or at total daily doses of more than 30mg.

Does Apuldon make your boobs bigger?

Apuldon works to raise levels of prolactin, which helps increase the production of breast milk. Apuldon is usually started at a dose of 10 milligrams (one tablet) three times a day.

Can I take Apuldon after meal?

Take your doses about half an hour before meals. If you take Apuldon after a meal, it will still work, but it may take longer to have an effect. Apuldon should be taken for a short period of time only. Your treatment will last no longer than seven days.

Does Apuldon increase blood pressure?

Apuldon increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.

Is Apuldon a laxative?

Apuldon is the only medication that is a true prokinetic with a low percentage of side effects that is useful in the treatment of certain GI conditions, including gastroparesis and other motility disorders.

Can I take Apuldon on an empty stomach?

The pharmacist may instruct you to take each does 30 minutes before eating, but that is because of its usual use for digestive problems. Taking Apuldon on an empty stomach does allow it to be better absorbed, but it is not necessary to do this for it to work to increase breastmilk production.

How does Apuldon work in the body?

Apuldon works by increasing the movement of food through the stomach and the digestive tract more quickly and in this way reduces the feeling of bloating, or fullness and indigestion. It also works by blocking the action of a chemical in your brain which causes the feeling of nausea and vomiting.

Is Apuldon good for gastritis?

Apuldon has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment. Apuldon is a kind of drug to strengthen gastric motility.

Where is Apuldon absorbed?

Apuldon is absorbed from the GI tract but has an oral bioavailability of only 20% in the dog. This is presumably due to a high first-pass effect. The drug is highly protein bound (93%). Peak levels occur about 2 h after dosing.

Can Apuldon cure gastroparesis?

The majority of patients remaining on treatment experienced an improvement in symptoms of gastroparesis, particularly postprandial fullness, nausea, vomiting, and stomach fullness. Thus, Apuldon treatment is beneficial for many patients with symptoms of gastroparesis.

How do I know if Apuldon is working?

Most breastfeeding mothers see an improvement in milk supply usually starting after the first week. If you are regularly expressing and taking the medication, the milk supply should improve within 3-4 weeks.

What is the half life of Apuldon?

In studies with severe renal insufficiency (serum creatinine > 6 mg/100 mL, i.e., > 0.6 mmol/L) the half-life of Apuldon is increased from 7.4 to 20.8 hours, but plasma drug levels are lower than in subjects with normal renal function.

Is Apuldon a laxative?

Apuldon has limited ability to cross the blood-brain barrier and therefore acts primarily as a peripheral antagonist. Thus, in contrast to metoclopramide, Apuldon rarely causes dystonic or extrapyramidal symptoms and it may increase prolactin levels and occasionally female patients may develop galactorrhea.

Is Apuldon safe for child?

Apuldon no longer approved for use in children due to a lack of efficacy. The use of Apuldon in newborns, infants, children (under 12) and adolescents weighing less than 35kg is no longer approved at European level.

Is Apuldon a hormone?

Apuldon is a drug which has, as a side effect, the increased production of the hormone prolactin. Prolactin is the hormone which stimulates the cells in the mother's breast to produce milk.