Aplet Tablet is manufactured by Aristopharma Ltd. Aplet Tablet contains 50 mg Cilostazol. It is Peripheral Vasodilator drugs: Intermittent Claudication class drug.
Aplet is a preparation of Aplet which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Aplet is used for the reduction of symptoms of intermittent claudication, as used by an increased walking distance.
|Therapeutic Class:||Peripheral Vasodilator drugs: Intermittent Claudication|
|Last Updated:||November 22, 2020 at 6:15 pm|
Table Of contents
Aplet contains Cilostazol 50 mg. Aplet Dosage:
The recommended dosage of Aplet is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner.
A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
Aplet should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Aplet and Clopidogrel.
Co-admin with drugs that affect CYP3A4 (erythromycin, other macrolides, diltiazem) or CYP2C19 (omeprazole) may influence the pharmacokinetics of cilostazol.
Pregnancy Lactation use
There are no adequate and well controlled studies in pregnant women. Transfer of Aplet into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Aplet.
Aplet is contraindicated in patients with congestive heart failure of any severity. Aplet is also contraindicated in patients with known or suspected hypersensitivity to any of its components.
Paediatric use: The safety and effectiveness of Aplet in paediatric patients have not been established.
Severe headache, diarrhoea, hypotension, tachycardia, and possibly cardiac arrhythmias. Careful observation and supportive treatment are recommended.
Interaction with other Medicine
Store in a cool & dry place, protected from light and moisture