Apigrel Tablet

Apigrel Tablet is manufactured by APC Pharma Ltd. Apigrel Tablet contains 75 mg+75 mg Clopidogrel + Aspirin. It is Anti-platelet drugs class drug.

Apigrel is a fixed-dose combination drug containing Clopidogrel and Aspirin. Clopidogrel is an inhibitor of platelet aggregation. Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Clopidogrel also inhibits platelet aggregation induced by agonists other than ADP by blocking the amplification of platelet activation released by ADP.

Aspirin is also an antiplatelet agent. Aspirin acts by causing irreversible inhibition of the cyclooxygenase enzyme, which leads to decreased formation of thromboxane A2 and ultimate inhibition of platelet aggregation.


Apigrel is used for the reduction of thrombotic events as follows:

Recent MI, Recent Stroke or Established Peripheral Arterial Disease

For patients with a history of recent myocardial infarction (MI), recent stroke or established peripheral arterial disease, Apigrel has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not) and other vascular death.


Acute Coronary Syndrome

For patients with acute coronary syndrome (unstable angina/non-Q-wave MI) including patients who are to be managed medically and those who are to be managed with percutaneous coronary intervention (with or without stent) or CABG. Apigrel has been shown to decrease the rate of a combined endpoint of cardiovascular death, MI, or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia.

Brand Name: Apigrel
Generic: Clopidogrel + Aspirin
Weight: 75 mg+75 mg
Type: Tablet
Therapeutic Class: Anti-platelet drugs
Manufacturer: APC Pharma Ltd
Price: 0.00
Last Updated: November 21, 2020 at 6:15 pm


Apigrel contains Clopidogrel + Aspirin 75 mg+75 mg. Apigrel Dosage:

Recent MI, Recent Stroke, or Established Peripheral Arterial Disease

The recommended daily dose of Apigrel one tablet daily.

Acute Coronary Syndrome

For patients with acute coronary syndrome (unstable angina/non-Q-wave MI), Apigrel should be initiated with a 4 tablet stat loading dose and then continued at one tablet daily.

Pediatric Use: Safety and effectiveness of Apigrel in the pediatric population has not been established.


Side Effects

The drug is generally well tolerated. Side effects that have been reported include abdominal pain, dyspepsia, gastritis, diarrhea, nausea, vomiting, constipation, gastrointestinal hemorrhage, ulceration, neutropenia, rash, palpitation, syncope, drowsiness, asthenia, neuralgia, paresthesia and vertigo.


General: As with other anti-platelet agents, this combination drug should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an anti-platelet effect is not desired, Apigrel should be discontinued 7 days prior to surgery.

GI Bleeding: The combination of Clopidogrel and Aspirin prolongs the bleeding time. So, it should be used with caution in patients who have lesions with a propensity to bleed (such as ulcers).

Thrombotic thrombocytopenic purpura (TTP): TTP has been reported rarely following use of Clopidogrel.

Reye\'s syndrome: Reye\'s syndrome may develop in individuals who have chicken pox, influenza or flu symptoms. This combination is not recommended for use in patients with chicken pox, influenza or flu symptoms.

Nasal polyps or nasal allergies: The combination drug of Clopidogrel and Aspirin should be administered with caution in patients with nasal polyps or nasal allergies.

Hepatic or Renal Impairment: This should be avoided in patients with impaired hepatic and renal function. Aspirin causes sodium and water retention in patients with renal impairment and increases the risk of gastrointestinal bleeding.



Salicylates should be used with caution in patients with a history of peptic ulceration or coagulation abnormalities. They may also induce gastro-intestinal haemorrhage occasionally major. Aspirin should be used with caution in patients with impaired renal function, hepatic function (avoid if severe) or in patients who are dehydrated. In large doses, it may also decrease insulin requirements.

Pregnancy Lactation use

Pregnancy: Adverse effects are increased in the mother and the fetus following chronic ingestion of Aspirin. Because of possible adverse effects on the neonate and the potential for increased maternal blood loss, Apigrel should be avoided during the last three months of pregnancy.

Lactation: Apigrel should be avoided in nursing mothers because of the possible risk of developing Reye\'s syndrome. Regular use of high doses of Aspirin could impair platelet function and produce hypoprothrombinemia in infants if neonatal vitamin K levels are low.


Hypersensitivity to Clopidogrel & Aspirin. Hypo-prothrombinaemia, haemophilia and active peptic ulceration, active pathological bleeding such as peptic ulcer or intracranial haemorrhage.

Special Warning

It should not be given to children, particularly those under 12 years, unless the expected benefits outweight the possible risks. Aspirin may be a contributory factor in the causation of Reye’s syndrome in some children.

Acute Overdose


Interaction with other Medicine


Storage Condition

Store in a cool and dry place, protected from light.