Anxium Tablet

Anxium Tablet is manufactured by Beacon Pharmaceuticals Ltd. Anxium Tablet contains 10 mg Clobazam. It is Benzodiazepine hypnotics class drug.

Anxium binds to one or more specific GABA receptors at several sites within the CNS including the limbic system and reticular formation. Increased permeability of neuronal membrane to chloride ions results in GABA's inhibitory effect leading to hyperpolarisation and stabilisation.

Uses

Anxium is used for anxiety, tension, irritability, restlessness, epilepsy and response in the treatment of fear, depressive mood, sleep disturbances.

Brand Name: Anxium
Generic: Clobazam
Weight: 10 mg
Type: Tablet
Therapeutic Class: Benzodiazepine hypnotics
Manufacturer: Beacon Pharmaceuticals Ltd
Price: 0.00
Last Updated: November 19, 2020 at 6:15 pm

Dosage

Anxium contains Clobazam 10 mg. Anxium Dosage:

Adults: 20-30 mg daily in divided dosage or as a single dosage at bed time, may increase up to 60 mg daily in divided dosage in severe anxiety and dosage of 20 mg daily for elderly, debilitated patients.

Children: Over 3 years up to ½ of the adult dose. Anxium is not recommended for children under 3 years of age.

Elderly: Doses of 20 mg daily may be used in the elderly patients with anxiety.

 

Side Effects

The most frequently observed adverse reactions, particularly during the initial phase of therapy include drowsiness, ataxia, fatigue, confusion, vertigo and these may diminish with continued therapy. Occasionally dry mouth, headache, hypersensitivity reactions and respiratory depression may occur.

Precaution

Anxium should be administered with caution to patients with hepatic or renal disease. The ability to operate machinery or drive a car may be impaired for patients taking high doses.

Anxium

Interaction

The administration of alcohol results in significantly higher serum concentrations of clobazam. The concurrent administration of hypnotic or antidepressants with sedative activity may cause an increase in side effects, particularly tiredness or drowsiness.

Pregnancy Lactation use

Pregnancy: There is little information on the use of Anxium in early pregnancy but no untoward effects have been found in animal studies. However, there are reports of a possible malformations in infants due to the administration of other benzodiazepines in early pregnancy.

Lactation: Anxium has been detected in the breast milk of nursing mothers, but the effect on the neonate is not known.

Contraindication

Anxium should not be used in patients known to be hypersensitive to benzodiazepines.

Special Warning

 

Acute Overdose

Symptom: Drowsiness, mental confusion, lethargy, ataxia, hypotonia, hypotension, respiratory depression, coma and very rarely death. 

Management: Treatment includes emptying stomach by inducing vomiting (if within 1 hr) or gastric lavage. Activated charcoal may be used to reduce absorption. Monitor respiratory and CV functions. Flumazenil may be given if necessary. Forced diuresis or haemodialysis unlikely to be effective.

Interaction with other Medicine

 

Storage Condition

Store at 15-30° C.