Anodyne SR Capsule (Sustained Release)

Anodyne SR Capsule (Sustained Release) is manufactured by Ibn-Sina Pharmaceuticals Ltd. Anodyne SR Capsule (Sustained Release) contains 100 mg Diclofenac Sodium. It is Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs) class drug.

Diclofenac, a phenylacetic acid derivative is a prototypical NSAID. It has potent anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits the enzyme, cyclooxygenase, thus resulting in reduced synthesis of prostaglandin precursors.

The anti-inflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.

Uses

Diclofenac sodium tablet, injection or suppository is used to relief all grades of pain and inflammation in a wide range of conditions including:

  • Arthritic conditions: Rheumatoid Arthritis, Osteoarthritis, Ankylosing spondylitis, Acute gout.
  • Acute musculoskeletal disorders such as periarthritis (e.g., frozen shoulder), tendinitis, tenosynovitis, bursitis.
  • Other painful conditions resulting from trauma, including fracture, low back pain, sprains, strains, dislocations, orthopaedic, dental and other minor surgery.

Diclofenac Gel

 is used for the local symptomatic relief of pain and inflammation in:

  • Trauma of the tendons, ligaments, muscles and joints, e.g, due to sprains, strains and bruises,
  • Localised forms of soft tissue rheumatism.
Brand Name: Anodyne SR
Generic: Diclofenac Sodium
Weight: 100 mg
Type: Capsule (Sustained Release)
Therapeutic Class: Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Manufacturer: Ibn-Sina Pharmaceuticals Ltd
Price: 4.55
Last Updated: June 9, 2021 at 3:56 pm

Dosage

Anodyne SR contains Diclofenac Sodium 100 mg. Anodyne SR Dosage:

Tablet/Suppository/Gel:

Adults:

  • Enteric coated tablet: A total of 75-150 mg daily given in two or three divided doses.
  • Sustained release tablets: One tablet daily, taken whole with liquid, preferably during meal.
  • Suppositories: 75-150 mg daily in divided doses.
  • Gel: Depending on the painful site to be treated, 2-4 g gel may be applied 3-4 times daily.

Children:

  • Enteric coated tablet: 1-3 mg/kg per day in divided doses.
  • Sustained release tablets: Not recommended.
  • Suppositories: 1-3 mg/kg body weight in divided doses.

Injection: 

Each 3 ml ampoule contains Anodyne SR 75 mg & each 2 ml ampoule contains Anodyne SR 75 mg and Lidocaine Hydrochloride 20 mg .

  • Adults: One ampoule once (or in severe cases, twice) daily by intramuscular injection.
  • Renal colic: One ampoule once daily intramuscularly. A further ampoule may be administered after 30 minutes, if necessary. The recommended maximum daily dose of diclofenac is 150 mg, by any route. The recommended maximum daily dose of lidocaine is 200 mg.
  • Children: In juvenile chronic arthritis, 1-3 mg of diclofenac/kg body wt. daily in divided doses.
  • Elderly patients: In elderly or debilitated patients, the lowest effective dosage is recommended, commensurate with age and physical status.

 

Side Effects

Side-effects of Diclofenac is usually mild and transient. It is generally well tolerated. At the starting of the treatment, however, patients may sometimes complain of gastrointestinal discomfort, epigastria pain, eructation, nausea and Diarrhoea, headache and bleeding sometime may occur. Occasionally skin rash, peripheral oedema and abnormalities of serum transaminase have been reported.Very rarely reported side effects include activation of peptic ulcer, haematemesis or melena, blood dyscrasia (extensive usage). There have been isolated reports of anaphylactoid reactions. The adverse effects due to Lidocaine mainly involve the CNS, are usually of short duration, and are dose related. The CNS reaction may be manifested by drowsiness, dizziness, disorientation, confusion, lightheadness, etc. Incase of eye drops ocular burning sensation or allergic reaction may occur in 5-10% patients.

Precaution

Patients with known CV disease or risk factors for CV disease, fluid retention or heart failure, SLE, HTN, history of GI disease. Patients who may be adversely affected by prolongation of bleeding time. Hepatic and renal impairment. Elderly. Lactation.

Anodyne SR

Interaction

May increase serum levels of methotrexate. Concomitant use with other NSAIDs or anticoagulants (e.g. warfarin) is associated with higher risk of GI bleeding. Increased risk of nephrotoxicity with ciclosporin or triamterene. May increase the risk of developing corneal complications in patients with significant pre-existing corneal inflammation when use concomitantly with ophth preparation containing corticosteroids. Colestyramine and colestipol reduce the bioavailability of diclofenac. Decreased plasma concentration when administered after sucralfate. Ophth application of diclofenac may reduce the efficacy of ophth acetylcholine and carbachol. May increase serum levels of lithium and digoxin.

Pregnancy Lactation use

Pregnancy: Diclofenac tablets and injection should not be prescribed during pregnancy, unless there are compelling reasons for doing so. The lowest effective dosage should be used. This type of drugs are not recommended during the last trimester of pregnancy. Very small quantities of Diclofenac may be detected in breast milk, but no undesirable effects on the infant are to be expected. Since no experience has been acquired with Diclofenac gel in pregnancy or lactation, it is not recommended for use in these circumstances.

Lactation: Very small quantities of Diclofenac may be detected in breast milk, but no undesirable effects on the infant are to be expected.

Contraindication

It is contra-indicated for those patients who are hypersensitive to Diclofenac. In patients with active or suspected peptic ulcer or gastrointestinal bleeding, or for those patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other NSAIDs possessing prostaglandin synthetase inhibitinig activity, it is also contraindicated.

Because of the presence of Lidocaine, it is also contraindicated for those patients who are hypersensitive to local anaesthetics of the amide type, although the incidence is very rare.

Special Warning

 

Acute Overdose

Symptoms: Lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding. HTN, acute renal failure, resp depression, anaphylactoid reactions and coma may occur rarely. 

Management: Symptomatic and supportive treatment. Immediately empty the stomach by inducing emesis or gastric lavage and admin of activated charcoal may be useful after.

Interaction with other Medicine

 

Storage Condition

Store in a cool and dry place, protected from light.

FAQ

What is Anodyne SR used for?

Anodyne SR is a medicine that reduces inflammation and pain. It's used to treat aches and pains, as well as problems with joints, muscles and bones. These include: rheumatoid arthritis, osteoarthritis and gout.

What are side effects of Anodyne SR?

Upset stomach, nausea, heartburn, diarrhea, constipation, gas, headache, drowsiness, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This medication may raise your blood pressure.

Is Anodyne SR stronger than tramadol?

Anodyne SR provides effective and better analgesia in acute post operative pain than tramadol. Also, tramadol requires more frequent administration than Anodyne SR.

Is Anodyne SR a muscle relaxer?

Anodyne SR is used to relieve pain and swelling (inflammation) from various mild to moderate painful conditions. It is used to treat muscle aches, backaches, dental pain, menstrual cramps, and sports injuries. It also reduces pain, swelling, and joint stiffness caused by arthritis.

What drugs interact with Anodyne SR?

Serious Interactions of Anodyne SR include:

  • apixaban
  • benazepril
  • captopril
  • enalapril
  • fosinopril
  • ketorolac
  • ketorolac intranasal
  • lisinopril
  • methotrexate
  • moexipril
  • pemetrexed
  • perindopril
  • pirfenidone
  • quinapril
  • ramipril
  • tacrolimus
  • trandolapril

What is Anodyne SR?

Anodyne SR (Diclofenac) is indicated for treatment of primary dysmenorrhea, for relief of mild to moderate pain, for relief of the signs and symptoms of osteoarthritis, for relief of the signs and symptoms of rheumatoid arthritis, for relief of symptoms of ankylosing spondylitis and for relief of acute migraine symptoms. Anodyne SR has analgesic, anti-inflammatory, and antipyretic properties.

Is Anodyne SR an antibiotic?

Anodyne SR has exhibited profound antibacterial effect against both gram-positive and gram-negative bacteria. It has also shown synergism with other antibiotics. These studies have suggested Anodyne SR as a potent non-antibiotic antibacterial agent.

Is Anodyne SR safe to take?

For most people, taking Anodyne SR is safe. However, if you have high blood pressure, high cholesterol, diabetes, your kidneys do not work very well or you smoke, you should check with your healthcare professional that this medicine is appropriate.

Is Anodyne SR a narcotic?

No, Anodyne SR is a non-steroidal anti inflammatory (NSAID) drug and in no way related to narcotics.

What happens if I drink on Anodyne SR?

Do not drink alcohol while taking Anodyne SR. Alcohol can increase your risk of stomach bleeding caused by Anodyne SR. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Can Anodyne SR treat infection?

The analgesic and anti-inflammatory properties of aspirin and Anodyne SR might represent an additional advantage for their use in the management of infections with Candida albicans.

How is Anodyne SR injection given?

Intramuscularly, deeply. The product is used for treatment of acute conditions or relief of chronic disease exacerbation. Single dose for adults is 75 mg (one ampoule). If necessary, repeated injection is possible, but not earlier than in 12 hours.

How long can I take Anodyne SR?

When used for severe or continuing arthritis, this medicine must be taken every day as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or longer may pass before you begin to feel better.

Is Anodyne SR safe during pregnancy?

Use of Anodyne SR during pregnancy is not advised unless prescribed by a doctor, especially if you are 30 or more weeks pregnant.

What is the side effect of Anodyne SR in pregnancy?

Anodyne SR may cause miscarriage (pregnancy loss), serious bleeding, or premature birth (baby is born too early) if taken during pregnancy.

Is Anodyne SR safe during breastfeeding?

Anodyne SR is not generally recommended in pregnancy or while breastfeeding. This is because diclofenac has been linked with a small risk of problems for your unborn baby if you take it in early or late pregnancy.