Angitrim MR Tablet
Angitrim MR Tablet is manufactured by Globe Pharmaceuticals Limited. Angitrim MR Tablet contains 35 mg Trimetazidine Dihydrochloride. It is Other Anti-anginal & Anti-ischaemic drugs class drug.
Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity, which results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. High fatty acid oxidation rates are detrimental during ischemia due to an inhibition of glucose oxidation leading to uncoupling of glycolysis and an increase in proton production, which has the potential to accelerate sodium and calcium overload in the heart. This leads to an exacerbation of ischemic injury and decreased cardiac efficiency during reperfusion.
Long-term treatment of Ischaemic heart disease (angina pectoris, sequelae of infarction).
|Brand Name:||Angitrim MR|
|Therapeutic Class:||Other Anti-anginal & Anti-ischaemic drugs|
|Manufacturer:||Globe Pharmaceuticals Limited|
|Last Updated:||June 9, 2021 at 6:23 pm|
Table Of contents
Angitrim MR contains Trimetazidine Dihydrochloride 35 mg. Angitrim MR Dosage:
One 20 mg tablet thrice daily after meals. No dosage adjustments are required in patients with impaired renal and hepatic function.
One 35 mg modified release tablet twice daily at mealtimes in the morning and evening.
Trimetazidine is safe and well tolerated. The most commonly encountered side effects are gastric discomfort, nausea, headache and vertigo. However, the side effects are mild and non-specific.
No drug interactions have so far been reported. In particular, no interactions of Trimetazidine with beta-blockers, calcium antagonists, nitrates, heparin, hypolipidemic agents or digitalis have been reported.
Pregnancy Lactation use
Pregnancy: Studies in animals have not demonstrated a teratogenic effect. However, in the absence of clinical data and for safety reasons, prescription should be avoided during pregnancy.
Nursing Mothers: There is no information on the secretion of Trimetazidine into breast milk. However, breast feeding should be discontinued if the use of Trimetazidine is considered essential.
Hypersensitivity to Angitrim MR.
Interaction with other Medicine
Store in a cool and dry place, protect from light and moisture. Keep out of the reach of children.
What does Angitrim MR used for?
Angitrim MR belongs to the class of medications called fatty acid oxidation inhibitors. It is used to prevent and treat the symptoms of angina (chest pain). Angina is caused by lack of blood supply and oxygen to your heart.
What are the side effects of Angitrim MR?
Angitrim MR has a significant side effects profile, with the most common adverse reactions being nausea, vomiting, fatigue, dizziness, and myalgia. The drug can induce or increase parkinsonian symptoms: extrapyramidal rigidity, bradykinesia, and tremor.
How long should Angitrim MR be taken?
Treatment with Angitrim MR added to the usual treatment for up to 18 months was well tolerated and induced functional improvement in patients with ischaemic dilated cardiomyopathy. Angitrim MR treatment was associated with a significant improvement of LV function and the remodelling process.
Is trimetazidine safe?
Angitrim MR has been generally very well tolerated in clinical trials and usually only isolated cases of adverse events (ADRs—adverse drug reactions) were observed during trimetazidine treatment (mainly gastrointestinal disturbances, vomiting, nausea).
Can I take Angitrim MR once a day?
Usually, Angitrim MR is taken twice, or three times, each day. A new altered form of Angitrim MR, which can be taken once a day, may improve patient-satisfaction.
Does Angitrim MR lower heart rate?
The dose of Angitrim MR does not affect hemodynamic stability, heart rate, blood pressure and speed-pressure multiplication, and it exerts no negative inotropic effect.
Can I stop taking Angitrim MR?
Angitrim MR must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Is Angitrim MR safe during Pregnancy?
There are no data from the use of Angitrim MR in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. As a precautionary measure, it is preferable to avoid the use of Angitrim MR during pregnancy.
Is Angitrim MR safe during breastfeeding?
There is no information on the secretion of Angitrim MR into breast milk. However, breastfeeding should be discontinued if the use of Angitrim MR is considered essential. The most commonly encountered side effects are gastric discomfort, nausea, headache and vertigo.
Is Angitrim MR a beta blocker?
Current anginal medications include beta-blockers and calcium antagonists, which decrease ischaemic severity by reducing cardiac workload, and nitrates, which increase coronary blood flow. A new therapeutic approach is the use of metabolic agents, such as Angitrim MR, which are cytoprotective during ischaemia.
What kind of drug is Angitrim MR?
Angitrim MR, a piperazine compound, is an antianginal drug widely used in France, and belongs to the group of partial fatty acid oxidation inhibitors (so-called PFox inhibitors). Angitrim MR has cardioprotective effects in animal models of ischemia.