Amitryl Tablet

Amitryl Tablet is manufactured by Cipla Ltd. Amitryl Tablet contains 10 mg Amitriptyline hydrochloride. It is Tricyclic Anti-depressant class drug.

Amitriptyline HCl is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system.

Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically, this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of Amitriptyline.


Amitriptyline is used for depressive illness, particularly with anxiety and nocturnal enuresis in children.

Brand Name: Amitryl
Generic: Amitriptyline hydrochloride
Weight: 10 mg
Type: Tablet
Therapeutic Class: Tricyclic Anti-depressant
Manufacturer: Cipla Ltd
Price: 0.00
Last Updated: November 22, 2020 at 6:15 pm


Amitryl contains Amitriptyline hydrochloride 10 mg. Amitryl Dosage:

Depression :

  • Adults: Initially 50-70 mg a day in divided dose or as a single dose at night at bed time.
  • Elderly and adolescents: 25-50 mg daily in divided doses or as single dose at bed time. Dose can be increased gradually as necessary to a maximum of 150-200 mg. Usual maintenance dose is 50-100 mg daily.

Nocturnal enuresis:

  • 6-10 years: 10-20 mg at bed time.
  • 11-16 years: 25-50 mg at bed time for up to 3 months and gradually withdrawn.


Side Effects

  • Cardiovascular reactions: Hypotension, syncope, postural hypotension, hypertension, tachycardia, palpitations, myocardial infarction, arrythmias, and heart block stroke.
  • CNS and neuromuscular: Confusional states, disturbed concentration disorientation, delusions, and hallucinations.
  • Anticholinergic: Dry mouth, blurred vision, mydriasis, increased intraoccular pressure, hyperplasia.
  • Allergic: Skin rash, urticaria, and photosensitization.
  • Haematological: Bone-marrow depression including agranulocytosis, leukopenia, eosinophilia, and thrombocytopenia.
  • Gastrointestinal: Nausea, epigastric distress, vomiting anorexia, diarrhoea.
  • Endocrine: Testicular swelling, gynaecomastia; breast enlargement, galactorrhoea.
  • Other reaction: Dizziness, weakness, fatigue, headache, weight loss


Schizophrenic patients may develop increased symptoms of psychosis; patients with paranoid symptomatology may have an exaggeration of such symptoms. Depressed patients, particularly those with known manic-depressive illness, may experience a shift to mania or hypomania. In these circumstances the dose of Amitriptyline may be reduced or a major tranquilizer such as perphenazine may be administered concurrently.

The possibility of suicide in depressed patients remains until significant remission occurs. Potentially suicidal patients should not have access to large quantities of this drug. Prescriptions should be written for the smallest amount feasible.

Concurrent administration of Amitryl and electroshock therapy may increase the hazards associated with such therapy. Such treatment should be limited to patients for whom it is essential.

When possible, the drug should be discontinued several days before elective surgery. Both elevation and lowering of blood sugar levels have been reported. Amitryl should be used with caution in patients with impaired liver function.



Monoamine oxidase inhibitors can potentiate the effects of Amitriptyline.

Anticholinergic agents: Amitriptylin should not be given with symptomatic agents such as adrenaline, epinephrine, isoprenaline, noradrenaline.

CNS depressant: Amitriptyline may enhance the response to alcohol, barbiturates.

Cemitidine: Cemitidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants.

Pregnancy Lactation use

Pregnancy Category C. Amitriptyline is not recommended during pregnancy, especially during the first and third trimester because the safety of Amitriptyline has not been established yet. 

Amitriptyline is detectable in breast milk. Because of the serious adverse reactions in infants from Amitriptyline, a decision should be made whether to continue breast feeding or discontinue the drug


Amitriptyline is contraindicated in myocardial infarction; arrythmias, particularly heartblock of any degree; mania; severe liver disease. Initially sedation may effect the ability to drive or operate machinery. It should be used with caution in patients with a history of epilepsy, glaucoma, urinary retention, prostatic hypertrophy, constipation, cardiac disease, diabetes, pregnancy, hepatic impairment, thyroid disease, increased intraoccular pressure, psychoses (may aggravate mania).

Special Warning


Acute Overdose


Interaction with other Medicine


Storage Condition

Keep containers well closed and stored below 25˚ C, protected from light.


What does Amitryl used for?

Amitryl is used for depressive illness, treating pain, back pain, prevent migraine attacks particularly with anxiety and nocturnal enuresis in children.

Does Amitryl a sleeping pill?

Amitryl has been around for many years and is an inexpensive option as a sleep aid. Amitryl and antidepressants like it are commonly used off-label to treat insomnia, especially in people who also have symptoms of depression.

What are the side effects of Amitryl?

Amitryl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • drowsiness
  • weakness or tiredness
  • nightmares
  • headaches
  • dry mouth
  • constipation
  • difficulty urinating
  • blurred vision
  • pain, burning, or tingling in the hands or feet
  • changes in sex drive or ability
  • excessive sweating
  • changes in appetite or weight
  • confusion
  • unsteadiness

How does Amitryl help with pain?

It works on two chemicals, noradrenaline and serotonin, that are found in nerves. When Amitryl is used to treat nerve pain, it lowers the pain signals to the brain. This helps to reduce the level of pain you experience, which can enable you to get back to your daily activities and have a better quality of life.

What drugs should not be taken with Amitryl?

Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication.

When should to take Amitryl?

It's usual to take Amitryl once a day before bedtime because it can make you feel sleepy. If you find that you are still feeling drowsy in the morning you could try taking it earlier in the evening.

How long before you go to bed should you take Amitryl?

Amitriptyline is available as tablets or syrup, taken daily. As it has a sedative effect and may make you drowsy, it's usually taken an hour or two before bedtime (but no later than 8 pm). Your doctor will advise you about the correct dose.

Can I drink coffee while taking Amitryl?

To avoid this interaction avoid coffee one hour before and two hours after taking medications for depression called tricyclic antidepressants. 

How long should I take Amitryl for nerve pain?

You may notice pain relief as quickly as two weeks after starting, but often Amitryl requires to be taken for six to eight weeks at the optimal dose level before one can say the drug has been given a fair trial.

What happens when I stop taking Amitryl?

If you stop taking the drug suddenly or don't take it at all: If you don't take Amitryl, your depression may worsen. If you stop taking this medication suddenly you may have withdrawal side effects such as nausea, headache, and tiredness.

Does Amitryl cause depression?

Amitryl may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

How do I stop taking Amitryl?

If you want to stop taking Amitryl, go to the doctor and they will help you to bring the dose down gradually. This will take a few weeks. You may still get some withdrawal effects, especially during the first two weeks as you reduce the dose. These effects will go away as you carry on reducing the dose.

How does amitriptyline work?

Amitriptyline is a type of medicine called a tricyclic antidepressant (TCA). These medications work by increasing certain brain chemicals called neurotransmitters like serotonin and norepinephrine to help improve mood, sleep, pain, and anxiety. It’s not clear exactly how amitriptyline works for sleep, but one of its effects is to block histamine, which may result in drowsiness. This is one reason doctors prescribe amitriptyline as a sleep aid.

What is Amitryl?

Amitryl is a prescription drug available as a tablet in several strengths. It’s approved for use to treat depression but is also often prescribed for several other conditions like pain, migraines, and insomnia. Although it has been around for many years, it is still a popular, low-cost generic medication.