Ambuterol Syrup

Ambuterol Syrup is manufactured by APC Pharma Ltd. Ambuterol Syrup contains 1 mg/ml Bambuterol Hydrochloride. It is Short-acting selective β2-adrenoceptor stimulants class drug.

Bambuterol is an adrenergic β2 receptor agonist which predominantly stimulates β2 receptor, thus producing relaxation of bronchial smooth muscle, inhibition of release of endogenous spasmogens, inhibition of edema caused by endogenous mediators & increased mucocilliary clearance.

Uses

Bambuterol is used for Bronchial asthma, chronic bronchitis, emphysema & other lung diseases where bronchospasm is a complicating factor.

Brand Name: Ambuterol
Generic: Bambuterol Hydrochloride
Weight: 1 mg/ml
Type: Syrup
Therapeutic Class: Short-acting selective β2-adrenoceptor stimulants
Manufacturer: APC Pharma Ltd
Price: 28.00
Last Updated: November 21, 2020 at 6:15 pm

Dosage

Ambuterol contains Bambuterol Hydrochloride 1 mg/ml. Ambuterol Dosage:

Adult or Elderly: The recommended initial dose 10 mg. The dose may be increased to 20 mg after 1-2 weeks depending on the clinical effect.

Children 2-5 years: The recommended normal dose 10 mg (10 ml syrup).

Children 6-12 years: The recommended normal dose 10 mg (10 ml syrup). The dose may be increased to 20 mg.

 

Side Effects

Common side effects are fatigue, nausea, palpitation, headache, dizziness & tremor.

Precaution

Reduce the dose in renal impairment, avoid in cirrhosis and severe hepatic impairment. Caution should be observed in patients with severe cardiovascular disorder, such as ischaemic heart disease, tachyarrhythmias or severe heart failure.

Ambuterol

Interaction

Succinylcholin, MAOIs (monoamine oxidase inhibitors), β2-blockers, corticosteroids, diuretics, muscle relaxants, sympathomimetic xanthine derivatives. Bambuterol may partly or totally inhibit the effect of β-blockers.

Pregnancy Lactation use

Pregnant women: There is no definite evidence of ill consequence during pregnancy. Nevertheless, the drug should not be used during the first trimester of pregnancy, unless the expected benefit is thought to outweigh any possible risk to the fetus.

Lactating mother: It is excreted in breast milk. So, patients taking this drug should not breast-feed.

Contraindication

Bambuterol is contraindicated in hepatic impairment, liver cirrhosis or severely impaired liver function.

Special Warning

Impaired renal function (GFR 50 ml/min): The recommended starting dose is 5 mg, which may be increased to 10 mg after one to two weeks, depending on the clinical effect.

Impaired hepatic function: Not recommended because of unpredictable conversion to terbutaline.

Acute Overdose

 

Interaction with other Medicine

 

Storage Condition

Keep away from light, store in a cool and dry place. Keep out of reach of children.

FAQ

What is Ambuterol?

Ambuterol is the hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. It has a role as an anti-asthmatic drug, a bronchodilator agent, a prodrug, a beta-adrenergic agonist, a sympathomimetic agent and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a hydrochloride, a carbamate ester and a member of phenylethanolamines. It contains a bambuterol.

What does Ambuterol used for?

Ambuterol are used to treat breathing problems in people with asthma and similar conditions. Ambuterol are used as regular treatment to prevent expected breathing problems. Ambuterol should not be used alone for the regular treatment of asthma or other breathing conditions. Ambuterol must only be used when your doctor has prescribed you another type of medication such as an “inhaled corticosteroid”, which helps reduce the swelling and inflammation in your lungs. However, Ambuterol will not relieve an acute asthma attack that has already started.

What are the side effects of Ambuterol?

Side effects of Ambuterol may include fatigue, nausea, palpitations, headache, dizziness and tremor.

What is the active metabolite of Ambuterol?

13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline.

Is Ambuterol safe during pregnancy?

There is no definite evidence of ill consequence during pregnancy. Nevertheless, Ambuterol should not be used during the first trimester of pregnancy, unless the expected benefit is thought to outweigh any possible risk to the fetus.

Is Ambuterol safe during breastfeeding?

Ambuterol is excreted in breast milk. So, patients taking this drug should not breast-feed.