Alton Tablet is manufactured by General Pharmaceuticals Ltd. Alton Tablet contains 20 mg Esomeprazole. It is Proton Pump Inhibitor class drug.
Alton is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in the gastric parietal cell. It is the S-isomer of omeprazole.
Alton is used for:
- Treatment of Gastroesophageal Reflux Disease (GERD)
- Healing of Erosive Esophagitis
- Maintenance of Healing of Erosive Esophagitis
- Symptomatic Gastroesophageal Reflux Disease
- H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence
- Zollinger-Ellison Syndrome
- Acid Related Dyspepsia
- Duodenal and Gastric Ulcer
|Therapeutic Class:||Proton Pump Inhibitor|
|Manufacturer:||General Pharmaceuticals Ltd|
|Last Updated:||November 20, 2020 at 6:15 pm|
Table Of contents
Alton contains Esomeprazole 20 mg. Alton Dosage:
Healing of erosive esophagitis: 20 mg or 40 mg once daily for 4 to 8 Weeks. For those patients who have not healed after 4-8 weeks of treatment, an additional 4-8 weeks course of Alton may be considered.
Long-term management of esophagitis: 20 mg once daily.
Symptomatic gastroesophageal reflux disease: 20 mg once daily for 4 weeks.
H. pylori eradication for treatment of duodenal ulcer:
Triple therapy: 20 mg Alton once daily with 500 mg Clarithromycin twice daily, and 1 g Amoxicillin twice daily for 7-10 days.
The recommended adult dose in GERD with Erosive Esophagitis is either 20 or 40 mg Alton given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 to 30 minutes). Pediatric dose (1 to 11 years old):
- Short term treatment of symptomatic GERD: 10 mg once daily for up to 8 weeks.
Healing of erosive esophagitis:
- Weight <20 kg: 10 mg once daily for up to 8 weeks.
- Weight ≥20 kg: 10 mg or 20 mg once daily for up to 8 weeks.
Directions for reconstitution of solution: Solution for injection is prepared by adding 5 ml of 0.9% Sodium Chloride for intravenous injection into the vial containing the dry powder. The reconstituted solution for injection is clear and colorless to very slightly yellow.
Preparations for Use and Administration of Alton 40 IV Injection: A solution for intravenous infusion is prepared by first reconstituting the contents of one vial with 5 ml of 0.9% Sodium Chloride and further diluting the resulting solution to a final volume of 50 ml. The resultant concentration after diluting to a final volume of 50 ml is 0.8 mg/ml.
- 20 mg dose: Withdraw 25 ml of the final solution and administer as an intravenous infusion over 10 minutes to 30 minutes.
- 10 mg dose: Withdraw 12.5 ml of the final solution and administer as an intravenous infusion over 10 minutes to 30 minutes.
In general, esomeprazole is well tolerated in both short and long term use. Adverse events reported with esomeprazole include headache, diarrhoea, nausea, flatulence, abdominal pain, constipation and dry mouth.
Symptomatic response to therapy with Alton does not preclude the presence of gastric malignancy. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole, of which Alton is an enantiomer.
Drug interaction studies have shown that Esomeparzole does not have any clinically significant interactions with Phenytoin, Warfarin, Quinidine, Clarithromycin or Amoxicillin. Alton inhibits gastric acid secretion. Therefore, Alton may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, Ketoconazole, Iron salts and Dogoxin). Coadministration of oral contraceptives, Diazepam, Phenytoin or Quinidine did not seem to change the pharmacokinetic profile of Alton.
Pregnancy Lactation use
Pregnancy: There are no adequate and well-controlled studies on the use of Alton in pregnant women. Therapeutic doses during pregnancy are unlikely to pose a substantial teratogenic risk. Alton should be used during pregnancy only if the potential benefit to pregnant women justifies the potential risk to the fetus.
Lactation: Alton is excreted in human milk. Thus, a decision should be taken to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Alton is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted Benzimidazoles.
Geriatric: Dosage adjustment is not necessary.
Pediatric: Safety and effectiveness in pediatric patients have not been established.
Hepatic insufficiency: No dosage adjustment is recommended for patients with mild to moderate hepatic insufficiency. However, in patients with severe hepatic insufficiency a dose of 20 mg once daily should not be exceeded.
Renal insufficiency: Dosage adjustment is not necessary.
There is no experience to data with deliverate overdose. Data are limited but single doses of 80 mg Alton were uneventful. Alton is extensively plasma protein bound and is therefore not readily dialyzable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilised.
Interaction with other Medicine
Store between 15-30°C. Protect from light.
What is Alton good for?
Alton reduces the amount of acid your stomach makes. It's used for heartburn, acid reflux and gastro-oesophageal reflux disease (GORD) - GORD is when you keep getting acid reflux. It's also taken to prevent and treat stomach ulcers.
What are the side effects of Alton?
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Incidence not known
- Blistering, peeling, or loosening of the skin
- darkened urine
- difficulty with swallowing
- fast heartbeat
- joint or muscle pain
- loss of appetite
- mood or mental changes
- muscle spasms (tetany) or twitching
- pains in the stomach, side, or abdomen, possibly radiating to the back
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- skin rash, hives, itching
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- tightness in the chest
- unusual tiredness or weakness
- yellow eyes or skin
Is esomeprazole better than omeprazole?
Esomeprazole was well tolerated. In conclusion, esomeprazole 40 mg provides more effective acid control than twice the standard dose of omeprazole.
How long should you take Alton?
Alton is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.
Can I take Alton after eating?
You can take Alton before or after food. If you forget to take a dose at your usual time, you can take it when you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.