Adafil Tablet is manufactured by Beximco Pharmaceuticals Ltd. Adafil Tablet contains 10 mg Tadalafil. It is Drugs for Erectile Dysfunction class drug.
When sexual stimulation causes the local release of nitric oxide in the corpus cavernosum, then nitric oxide activates the enzyme guanylyl cyclase, which results in increased levels of cGMP. The increased levels of cGMP in the corpus cavernosum produce smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. PDE5 degrades cGMP in the corpus cavernosum, and the inhibition of PDE5 by Adafil maintains increased levels of cGMP in the corpus cavernosum. Adafil has no effect on penile blood flow in absence of sexual stimulation.
Adafil is used for the treatment of erectile dysfunction (ED).
Adafil is used for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).
Adafil is used for the treatment of erectile dysfunction and the signs of benign prostatic hyperplasia (ED/BPH).
|Therapeutic Class:||Drugs for Erectile Dysfunction|
|Manufacturer:||Beximco Pharmaceuticals Ltd|
|Last Updated:||November 21, 2020 at 6:15 pm|
Table Of contents
Adafil contains Tadalafil 10 mg. Adafil Dosage:
For Use as Needed:
- The recommended starting dose of Adafil for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity.
- The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients.
For Once Daily Use:
- The recommended starting dose of Adafil for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
- The Adafil dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.
Patients with BPH or with ED and BPH-
- Intimate for once daily use for BPH: The recommended dose of Intimate for once daily use is 5 mg, taken at approximately the same time every day.
- Intimate for once daily use for ED+BPH: The recommended dose of Intimate for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
Adafil may be taken without regard to food.
Body as a whole: hypersensitivity reactions including rash, urticaria, facial edema, Stevens-Johnson syndrome, and exfoliative dermatitis.
Cardiovascular and cerebrovascular: Serious cardiovascular events, including myocardial infarction, sudden cardiac death, unstable angina pectoris, ventricular arrhythmia, stroke, transient ischemic attacks, chest pain, palpitations, and tachycardia, may occur. Most of the patients in whom these events have been reported had pre-existing cardiovascular risk factors. Hypotension (more commonly reported when tadalafil is given to patients who are already taking antihypertensive agents), hypertension, and syncope.
Skin and subcutaneous tissues: hyperhidrosis (sweating).
Gastrointestinal: abdominal pain and gastroesophageal reflux.
Nervous system: migraine, transient global amnesia.Respiratory system: epistaxis (nose bleed).
Special senses: blurred vision, nonarteritic anterior ischemic optic neuropathy, retinal vein occlusion, visual field defect.
Otologic: cases of sudden decrease or loss of hearing have been reported.
Cardiovascular: Physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Potential for Drug Interactions When Taking Adafil for Once Daily Use Physicians should be aware that Adafil for once daily use provides continuous plasma Adafil levels and should consider this when evaluating the potential for interactions with medications (e.g., nitrates, alpha-blockers, anti-hypertensives and potent inhibitors of CYP3A4).
Prolonged Erection: There have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds. Priapism, if not treated promptly, can result in irreversible damage to the erectile tissue. Patients who have an erection lasting greater than 4 hours, whether painful or not, should seek emergency medical attention. Adafil should be used with caution in patients who have conditions that might predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia), or in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronie’s disease).
Eye & Sudden Hearing Loss: Physicians should advise patients to stop use of all PDE5 inhibitors, including Adafil, and seek medical attention in the event of a sudden loss of vision in one or both eyes & sudden decrease or loss of hearing.
Alpha blockers and Antihypertensives: Physicians should discuss with patients the potential for Adafil to augment the blood-pressure-lowering effect of alpha blockers and antihypertensive medications. Caution is advised when PDE5 inhibitors are coadministered with alpha blockers Renal Insufficiency, Hepatic Impairment, Consumption of alcohol.
Pregnancy Lactation use
It is not indicated for use in newborn, children or women.
Nitrates: Administration of tadalafil to patients who are using any form of organic nitrate, either regularly and/or intermittently, is contraindicated. In clinical pharmacology studies, tadalafil was shown to potentiate the hypotensive effect of nitrates.
Hypersensitivity Reactions: Adafil is contraindicated in patients with a known serious hypersensitivity to tadalafil. Hypersensitivity reactions have been reported, including Stevens-Johnson syndrome and exfoliative dermatitis.
For Use as Needed:
- Mild (creatinine clearance 51 to 80 mL/min): No dose adjustment is required.
- Moderate (creatinine clearance 31 to 50 mL/min): A starting dose of 5 mg not more than once per day is recommended, and the,maximum dose should be limited to 10 mg not more than once in every 48 hours.
- Severe (creatinine clearance <30 mL/min and on hemodialysis): The maximum recommended dose is 5 mg not more than once in every 72 hours.
For Once Daily Use:
- Mild (creatinine clearance 51 to 80 mL/min): No dose adjustment is required. Moderate (creatinine clearance 31 to 50 mL/min): No dose adjustment is required.
- Severe (creatinine clearance <30 mL/min and on hemodialysis): Adafil for once daily use is not recommended.
For Use as Needed:
- Mild or moderate: The dose should not exceed 10 mg once per day.
- Severe: Not recommended
For Once Daily Use:
- Mild or moderate: Adafil for once daily use has not been extensively evaluated in patients with hepatic insufficiency. Therefore, caution is advised if Adafil for once daily use is prescribed to these patients.
- Severe: Not recommended.
No dose adjustment is required in patients >65 years of age
Adverse events were similar to those seen at lower doses. In case of overdose, standard supportive measure should be adopted as required
Interaction with other Medicine
Store below 30° C. Protect from light and moisture. Keep out of reach of children.
Can I take Adafil daily?
A daily dose of 5mg Adafil can be safely used in the treatment of erectile dysfunction and LUTS, that prolongs the ejaculatory latency time. Source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433372/
What are the side effects of Adafil?
Headache, stomach upset, back pain, muscle pain, stuffy nose, flushing, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Does Adafil a safe medication?
Generally, Adafil is a safe drug but is not recommended to be taken if you have certain conditions or are taking specific medications that might interact with tadalafil.
When should you not take Adafil?
Before using Adafil, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure), stroke in the past 6 months, kidney disease, liver disease, high or low blood pressure, a severe loss of body water (dehydration), penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease), history of painful/prolonged erection (priapism), conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma), eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION), bleeding disorders, active stomach ulcers.
Does Adafil raise blood pressure?
Adafil can slightly lower blood pressure. This is not a problem for most men, but Adafil' effect on blood pressure is exaggerated if the Adafil is taken with a nitrate drug. Nitrates are one of the treatments doctors prescribe for angina.