Acmegra Tablet is manufactured by Acme Laboratories Limited. Acmegra Tablet contains 50 mg Sildenafil Citrate. It is Drugs for Erectile Dysfunction class drug.
Acmegra belongs to a group of medicines called phosphodiesterase type-5 (PDE-5) inhibitors. It works by helping to relax the blood vessels of penis, allowing blood to flow into penis. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. When sexual stimulation causes local release of NO, inhibition of PDE-5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.
Acmegra is used for the treatment of Erectile Dysfunction.
|Therapeutic Class:||Drugs for Erectile Dysfunction|
|Manufacturer:||Acme Laboratories Limited|
|Last Updated:||November 20, 2020 at 6:15 pm|
Table Of contents
Acmegra contains Sildenafil Citrate 50 mg. Acmegra Dosage:
The usual starting dose of Sildenafil is 50 mg once daily. lt should be taken before 30-40 minutes of intercourse. Depending on effectiveness and tolerance; the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum dosing frequency is once per day.
Some factors are associated with increased plasma levels of sildenafil: age>65, hepatic impairment, severe renal impairment and concomitant use of ketoconazole, itraconazole, erythromycin. Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients.
Sildenafil may takes longer time to work if you take it with a heavy meal.
Like all medicines, Sildenafil can cause side effects although not everybody gets them.The side effects reported in association with the use of Sildenafil are usually mild to moderate and of a short duration. All medicines including Sildenafil can cause allergic reactions.
Contact with doctors immediately if experiences any of the following symptoms after taking Sildenafil: sudden wheeziness, difficulty in breathing or dizziness, swelling of the eyelids, face, lips or throat. Common side effect includes headache, facial flushing, indigestion, effects on vision, light sensitivity, blurred vision or reduced, stuffy nose and dizziness. Uncommon side effect includes vomiting, skin rash, bleeding at the back of the eye, red eyes, eye pain, double vision, abnormal sensation in the eye, irregular or rapid heartbeat, muscle pain, feeling sleepy, reduced sense of touch, vertigo, ringing in the ears, nausea, dry mouth, chest pain & feeling tired.
Warnings: In patients with preexisting cardiovascular disease, there is a potential risk in sexual activity. Sildenafil should not be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status. Sildenafil has systemic vasodilatory properties (mean maximum decrease of 8.4/5.5 mmHg). Patients with left ventricular outflow obstruction (e.g. aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood can be particularly sensitive to the actions of vasodilators including Sildenafil.There is no controlled clinical data on the safety or efficacy of Sildenafil in Patients who have suffered from a myocardial infarction, stroke, or life-threatening arrhythmia within the last 6 months. Caution should be taken in patients with resting hypotension (BP <90/50) or hypertension (BP >170/110), cardiac failure or coronary artery disease causing unstable angina, retinitis pigmentosa. Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Sildenafil. In this situation, patient should seek immediate medical assistance.
Precautions: Please tell your doctor or pharmacist if you are taking or have recently taken other medicines, including medicines obtained without prescription. Sildenafil tablets may interfere with some medicines, especially those used to treat chest pain. In the event of a medical emergency, you should tell the healthcare professional treating your condition that you have taken Sildenafil and if you did, do not take Sildenafil with other medicines unless your doctor tells you can.You should not take Sildenafil if you are taking medicines called nitrates as the combination of these products may cause a potentially dangerous decrease in your blood pressure. Always tell your doctor or pharmacist if you are taking any of these medicines that are often used for the relief of angina pectoris (or chest painJ.You should not take Sildenafil if you are using any of the drugs known as nitric oxide donors such as amyl nitrite as the combination may also lead to potentially dangerous decrease in your blood pressure. If you are taking medicines known as protease inhibitors, such as for the treatment of HIV, your doctor may start you on the lowest dose (25 mg) of Sildenafil. Some patients who take alpha-blocker therapy for the treatment of high blood pressure or prostate enlargement may experience dizziness or light-headedness, which may be caused by low blood pressure upon sitting or standing up quickly. Certain patients have experienced these symptoms when taking Sildenafil with alpha-blocker. This is most likely to occur within 4 hours after taking Sildenafil. In order to reduce the likelihood of these symptoms occur,you should be on a regular daily dose of your alpha-blocker before you start Sildenafil. Your doctor may start you on a lower dose (2S mg) of Sildenafil if you have hypotension (avoid if systolic blood pressure below 90 mmHg), recent stroke, unstable angina & myocardial infarction. Drinking alcohol can temporally impair your ability to get an erection, to get the maximum benefit from your medicine; you are advised not to drink excessive amounts of alcohol before taking Sildenafil.
Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Symptomatic hypotension when used with α-blockers. Plasma concentrations are increased by ritonavir.
Pregnancy Lactation use
Sildenafil is not indicated for use in newborns, children & women.
Sildenafil was shown to potentiate the hypotensive effects of nitrates and its administration to patients who are using organic nitrates, either regularly and or intermittently, in any form is therefore contraindicated.
In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates and severities were increased. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine.
Interaction with other Medicine
Store below 30° C. Protect from light and moisture. Keep out of reach of children.
Why does Acmegra use?
Acmegra is used to treat erectile dysfunction (difficulty obtaining or maintaining erections). These drugs increase blood flow to the penis following sexual arousal, helping to produce an erection. They do not inhibit ejaculation, so they are not prescribed for premature ejaculation.
When is the best time to take Acmegra?
Take Acmegra as needed before sexual activity. The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity.
Does Acmegra increase penis size?
If you have erectile dysfunction and normally find it difficult to get a complete erection, Acmegra might cause your erection to feel bigger than normal. However, it will not make your penis physically larger than its regular size.
Can I take Acmegra with alcohol?
While one or two drinks is unlikely to stop Acmegra from working, excessive alcohol consumption may affect the ability of the medication to work. Overall, there is no major interaction between Acmegra and alcohol. However, excessive alcohol use may limit the ability for Acmegra to work.
How should I take Acmegra for best results?
To treat erectile dysfunction-ED, take this drug by mouth as directed by your doctor, usually as needed. Take Acmegra at least 30 minutes, but no more than 4 hours, before sexual activity (1 hour before is the most effective). Do not take more than once daily.
What drugs should not be taken with Acmegra?
Do not take Acmegra if you are taking or have recently taken riociguat (Adempas) or nitrates (medications for chest pain) such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others).
How can I make Acmegra work better?
- Eat a light meal beforehand. Acmegra can be taken with or without food, but if you like to fuel up before getting busy, try to keep your meal choice light.
- Give yourself time for it to work.
- Don't drink alcohol after taking.
- Get in the mood.
Is it best to take Acmegra on an empty stomach?
Acmegra can be taken with or without food, but it works faster on an empty stomach. Acmegra takes longer to start working if you take it with or after a meal.
Does Acmegra bad for your heart?
While Acmegra is more widely known for helping genital blood vessels expand to maintain an erection and, more recently, as a treatment for pulmonary hypertension, it has been thought to have little direct effect on the human heart.
Can Acmegra cause heart attack?
Even when a man isn't taking nitrates, there's been concern that Acmegra might make his underlying heart disease much worse. There have been reports of men suffering heart attacks or chest pain after taking the popular erectile dysfunction drug.
Why is Acmegra bad for the heart?
The problem is their effect on arteries. All arteries, not just those in the penis, generate nitric oxide, so any artery can widen in response to Viagra, Acmegra, causing blood pressure to drop temporarily by 5-8 mmHg, even in healthy men.
What are the side effects of Acmegra?
Dizziness, headache, flushing, or stomach upset may occur. Vision changes such as increased sensitivity to light, blurred vision, or trouble telling blue and green colors apart may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What happens when a man takes Acmegra?
Acmegra is a PDE5 inhibitor, meaning it inhibits the specific enzyme that regulates blood flow to the soft tissue of the penis. When you take Acmegra, the blood vessels bringing blood to and around your penis dilate, letting more blood flow into the penis and making it easier to get an erection.
How long does Acmegra last for?
Sildenafil (Acmegra) for ED (erectile dysfunction) lasts about four hours. It reaches peak concentrations in about an hour, so it's best to take sildenafil 30 to 60 minutes before sex. While you can take it up to four hours beforehand, the effects will decrease after two hours or so.
Can I take Acmegra everyday?
Acmegra is a medication which you can take regularly. It is safe to take every day, starting at 25mg or 50mg per dose with the option to go up to a 100mg dose for those who need it. But must consult with doctor.
Will Acmegra make me bigger?
Sildenafil (Acmegra) is a medication for erectile dysfunction (ED). It works by enabling blood flow to the penis by inhibiting an enzyme that causes an erection to deflate. Acmegra can make your erection seem firmer and therefore bigger. But it won't increase the size of your penis permanently.
Why does Acmegra not work?
Hormonal issues, such as low testosterone, can also affect your level of sexual desire, preventing you from getting an erection even with Acmegra. If you believe your ED might be caused by an underlying physical health condition, it's important to talk to your doctor.
Does Acmegra really work?
Acmegra was significantly more effective than placebo in erectile dysfunction of all tested causes. The efficacy of Acmegra was not affected by patient age (> or < or =65 years) or by antihypertensive or antidepressant medications. The drug was effective in patients with severe erectile dysfunction.
How long can the average man stay erect?
An erection can last from a few minutes to about half an hour. On average, men have five erections a night while they're sleeping, each lasting about 25 to 35 minutes.
What happens if a female takes Acmegra?
We know that in men, Acmegra dilates blood vessels and increases the flow of blood to the penis. Women who take it might also have increased blood flow to the genitals. That may help increase sensitivity, arousal, and orgasmic function.
Can women take Acmegra?
The Food and Drug Administration (FDA) has not approved Acmegra for use in women. But your doctor can prescribe it for off-label use.
Is Acmegra safe in women?
There’s little data on safety in women, particularly in the long term. In studies that have included women, it appears to be fairly well-tolerated. Side effects have included:
- nasal congestion
- visual disturbances
How much Acmegra should a woman take?
In studies on women, doses have generally ranged from 10 to 100 milligrams. The product label doesn’t include dosing information for women because it’s not intended for this use.
If you do plan on taking Viagra, consider the source. Some online sites that claim to sell Viagra are selling counterfeit drugs. These may not work like Viagra and may not be safe.
To access the real thing, you’ll need a prescription. A doctor will decide on the dose and provide safety information.
Is there a Acmegra for women?
Acmegra is an ED medication that improves blood flow to the penis. Acmegra is a trade name and there’s no “Acmegra for women.”
Can I take Acmegra with milk?
You can take Acmegra with a glass of water, but you can also take it with milk or a light snack. Keep in mind that taking Acmegra with whole milk or food may impact its effectiveness. Always talk to your doctor or pharmacist about the best way to take Acmegra, including if there are foods or drinks you should avoid.
What happens if I take 2 Acmegra?
Never take more than 100 mg of Acmegra in a 24-hour period. Taking too much Acmegra can cause priapism, a painful erection that lasts longer than 4 hours. This can damage penis tissue because blood stored in the penis isn't receiving any oxygen. Get emergency treatment right away if this happens.
What is the average age for a man to take Acmegra?
It's true that erectile dysfunction is more common in older men, but many potential Acmegra users are hardly senior citizens: About 40% of 40-year-old men in the U.S. have some degree of erectile dysfunction. Most Acmegra users today, according to Pfizer, are in their early to mid 50s.
How do I get the best results from Acmegra?
- Timing is everything. Viagra should be taken orally 30 minutes to four hours before sexual activity but is most effective if taken one hour beforehand.
- Take the prescribed amount. The standard dose is 50 mg taken with or without food.
- Sexual stimulation is required. Viagra may not work the first time for everyone.